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3 parts of the cardiovascular system
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how many liters of blood is in a small drop
4-6 liters
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normal range of pH of blood
7.35-7.45
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55% of whole blood
plasma
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-
Plasma is ___ % water, ____ % nutrients, waste, hormones, proteins
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Most abundant protein in plasma
albumin
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Allows water in the blood
albumin
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Three types of cells
- red blood cells
- white blood cells
- platelets
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forms red blood cells
hemopoietic tissue
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RBC, WBC, platelets originate from
hemocytoblast
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Technical name for RBC
erythrocyte
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Normal value for RBC
4.5-6 million per mm3
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percent of whole blood of RBC's
hematocrit
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hematocrits are what shape and function?
-
how long do RBC live
120 days
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pigment protein that gives RBC the red color
hemoglobin
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globin is made of
amino acids
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oxygen bound
oxyhemoglobin
-
oxygen not bound
deoxyhemoglobin
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CO2 bound
carbaminohemoglobin
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normal value range of hemoglobin
12-18 g
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kidneys detect low oxygen and secrete which hormone?
erythropoietin (EPO)
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EPO's target to produce red blood cells
red bone marrow
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destroys RBC because they contain macrophages
spleen
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Iron is converted to
bilirubin
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bile color comes from
bilirubin
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bilirubin in tissues instead of bile
jaundice
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low RBC or low hemoglobin
Anemia
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three types of anemia
- iron deficiency
- pernicious
- sickle cell
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type of anemia that results in tired, low energy, and pale; more common in females
iron deficiency
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type of anermia due to lack of vitamine B12 or lack of intrinsic factor
pernicious
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type of anemia that is caused by a genetic mutation caused by a mistake in lining of amino acids which results in blockages
sickle cell
-
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Blood type A contains antigen _____ and antibodies ____
- antigen = A
- antibodies = B
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Blood type B contains antigen ___ and antibodies ___
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Blood type AB has antigen ____ and antibodies ____
- antigen= A and B
- Antibodies= n/a
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Blood type O contains ____ antigen and ____ antibodies
- antigen= n/a
- antibodies= A & B
-
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___ % of the population is Rh Positive
85
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-
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technical name for WBC
leukocytes
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normal value range for WBC in a drop of blood
5,000-10,000 mm3
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increase in WBC (infection)
leukocytosis
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decrease in WBC (at risk)
leukopenia
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Two categories of WBC
- Granulocytes
- Agranulocytes
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Three types of granulocytes
- neutrophils
- basophils
- eosinphils
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Neutral stain (lavender); 3 to 6 lobed nucleus
neutrophils
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WBC function is to eat small invaders
neutrophils
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red stain; 2 lobed nucleus
eosinophils
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WBC function is to elevate in allergic reaction or parasitic worms to lessen reaction or take out worms
eosinophils
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Base stain (dark purple); large granules with S-shaped nucleus
basophils
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WBC function is to cause redness (inflammation)
basophils
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found in basophils and responsible for anti-coagulant (clotting)
heparin
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found in basophils and responsible for daialated blood vessels
histamines
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two types of agranulocytes
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2 subcategories of lymphocytes
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WBC mostly made of nucleus
lymphocytes
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recognize foreign antigens and trigger immune response
T-cell
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produce antibodies
B-cell
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Big cell with kidney nucleus that convert to a macrophage
monocytes
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Order of differential
- Neutrophils 50-70
- Lymphocytes 25-45
- Monocytes 3-8
- Eosinophils 2-4
- Basophils .5-1
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pieces of cells that pinch off into blood
platelets
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technical term for platelets
Thromocytes
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convert to platelets
megakaryocytes
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normal range for platelets
150,000-300,000 mm3
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decrease in platelets which leads to bruise and bleeding very easily
thrombocytopenia
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control of blood loss
hemostasis
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3 ways of hemostasis
- platelet plug
- vascular spasm
- fibrin
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the platelets adhere to collagen fibers at the injured sport and become sticky so more platelets will come
platelet plug
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constrict injured vessel
vascular spasm
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What vitamin for you need to produce prothrombin?
Vitamin K
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-
Flow of hemostasis
- Injured vesserl
- a) platelet plug or b) vascular spasm
- release prothrombin activator
- combine with Ca and clotting factors
- to produce thrombin
- which activates fibrinogen
- and turns into fibrin
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opposes platelets
aspring
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keeps from forming thrombin
heparin
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opposes formation of prothrombin
coumadin
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TPA (tissue plasminogen activator) turns into plasminogen then into plasma which
digests fibrin
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clot in an intact vessel
thrombus
-
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3 membranes that cover heart
- fibrous pericardium
- parietal pericardium
- visceral pericardium
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parietal and visceral pericardium combine to form
serous membrane
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Three layers of heart
- epicardium
- myocardium
- endocardium
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outer msot layer of heart
epicardium
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thickest, middle part of the heart; muscle
myocardium
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innter most layer of the heart
endocardium
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4 chambers of the heart
- 2 upper-atria
- 2 lower- ventricle
-
-
4 valves
- tricuspid valve
- pulmonary semilunar valve
- bi cuspid (mitral )
- aortic semilunar valve
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vessels that bring blood flow into the heart
veins
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vessels that bring blood flow out of the heart
arteries
-
3 Vessels in Right atrium
- superior vena cava
- inferior vena cava
- coronary sinus
-
drains blood from head and neck
superior vena cava
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drains blood from lower body
inferior vena cava
-
drains blood into the heart
coronary sinus
-
Right side blood flow
- Right atrium
- tricuspid valve
- right ventricle
- pulmonary semilunar valve
- pulmonary trunk
- pulmonary arteries
- lungs
- loosing CO2 and gaining 02
-
Right side blood flow is
deoxygenated
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Left side of blood flow is
oxygenated blood
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Left side blood flow
- Pulmonary arteries
- Left atrium
- Bicuspid valve
- Left ventricle
- Aortic semilunar valve
- aorta
- arteries
- body
- dropping off 02
- picking up co2 and wastes
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1st heart sound
cuspids closing
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2nd heart sound
semilunar valve closing
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hole in the fetal heart that helps bipass Right atrium into left atrium
foramen valve
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foramen valve closes at or before birth and becomes
fossa ovalis
-
function of the right heart
pulmonary circulation
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function of the left heart
systemic circuit
-
heart attack where piece of heart died
myocardial infarction
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warning sign that heart muscle is low in O2; and it will turn into myocarial infarction
angina pectoris
-
4 steps of the cardiac conduction
- SA node
- AV node
- Bundle of his (AV bundle)
- Purkinjie fibers
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The "pacemaker" that fires impulses travels thru atria
SA node
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Electrical events of heart measured by
EKG (electrocardigram)
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measures heart beat
electrocardigram
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In one heart beat what are the waves?
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atrial depolarization
P-wave
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ventricular depoarization
QRS complex
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ventricular replarization
T wave
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events of heart in one beat
cardiac cycle
-
2 events in a cardiac cycle
- atrial contraction
- ventricular contraction
-
-
-
normal value for resting heart rate
70-100 bpm
-
Three Mechanical stages of Cardiac Cycle
- ventricular filling
- ventricle systole
- isovolumetric relaxation
-
ventricles fill with blood from atria
ventricular filling
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atria drains by gravity ___ %
squeezes ___ % into ventricles
-
during ventricular filling, cuspid valves are _____ and semilunar valves are _____
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two steps to ventricle systole
- isovolumetric contraction
- ventricular ejection
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all valves are shut and ventricles are contracting while pressure is rising
isovolumetric contraction
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semilunar valves are open but the pressure in ventricles have exceeded pressure in trunk
cuspid are close and semilunar are open
ventricular ejection
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all valves are shut while ventriles are relaxing and atria is filling with blood
isovolumetric relaxation
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the amount of blood put out of the left ventricle in one minute
cardiac output
-
formuka for cardiac output
Stroke Volume x Heart Rate= Cardiac Output
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amount of blood put out of the heart in one beat
stroke volume
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3 things that dertermine amount of blood put out of the heart
- preload
- contractility
- after load
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venous retunr; skeletal muscle contraction
preload
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force of muscle itself contracting
Starlings Law
sympatheric Nervous system
contractility
-
the back pressure exerted by pulmonary trunk and aorta
afterload
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more stretch of muscle = contract with more force
starlings law
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Three categories of Blood Vessels
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function of cardiovascular
capillaries
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3 arteries/veins layers
- tunica externa
- tunica media
- tunica intima
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outside layer that contains collagen and elastin that helps with strength
tunica externa
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middle layer that is made up of smooth muscle in charge of constricting and dialiating
tunica media
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inner layer made up of endothelium smooth lining
tunica intima
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2 types of arteries
- elastic artery
- muscular artery
- arteriole
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artery that is clsoer to the heart
elastic artery
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distribuiting artery
muscular artery
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smaller version of artery
arteriole
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Veins do not have a lot of ______ because they are not under high pressure
elastin
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veins contain a larger ____
lumen
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are capable of collapsing
veins
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small version of vein
venule
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layer for capillaries
simple squamous epithelial tissue
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capillaries tissue layer allow _____ to take place
diffusion
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Artery/vein flow
artery--> arteriold--> capillary--> venule--> vein
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more stretch= more force = increase _____
stroke volume
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ex of a way to bring more blood to heart
activity (moving, breathing
-
lose blood = decrease dtroke volume = increase ___
heart rate
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expansion and recoil of the arterial with each heart beat
pulse
-
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vein found on side of head by temple
temporal artery
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artery found on the sides of the neck
common carotid
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used for blood pressure and found at the bend of the elbow
brachial artery
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artery used to find babies pulse
brachial
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artery found on thumb side of hand
radial artery
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artery found by groin
femoral artery
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artery located behind the knee
popliteal artery
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artery on the back of the foot
dorsalis pedis
-
test for circulation
dorsalis pedis artery
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use arteries to test for what two things
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the force that blood hits the vessel wall
blood pressure
-
for fat people, which artery would you test?
femoral
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normal blood pressure fraction:
120/88 mm Hg
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Blood pressure top number
systolic pressure
-
blood pressure bottom number
diastolic pressure
-
What three things effect blood pressure?
- blood volume
- peripheral resistane
- cardiac output
-
how much blood you have in the system
blood volume
-
two hormones that increase blood volume
-
opposing force offered by vessel wall
peripheral resistance
-
3 effects of peripheral resistance
- vessel length
- diameter
- viscosity
-
increased vessel length= increased peripheral resistance= ________
increased blood pressure
-
decrease diameter= increased peripheral resistance= _____
increased blood pressure
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how thick the blood is
viscosity
-
increased viscosity= ___ blood pressure
increased
-
increased cardiac output = ____ blood pressure
increased
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Kidneys detect low blood pressure release hormone renin
renin- angiotesin mechanism
-
kidneys detect low BP and release hormone
renin
-
brings about angiotensinogen
renin
-
angiotensinogen makes
angiotensin 2
-
3 functions of angiotensin 2
- vasoconstrict
- stimulate adrenal cortex to produce aldosterone
- stimulate post. pituitary to release ADH
-
produced in atrium and tells kidneys to excrete sodium
ANH (atrial naturetic hormone)
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