Muscle relaxants

• Long onset 3-5
• Long Duration 30-60
• Most not metabolized (60% renal)
• Blocks Nn, Dec BP, inc HR, inc [Histamine] alot
• Dont use in asthmatics, allerges, or hypotensive patients

• Long 3-5
• Intermediate 30
• 85% liver metabolized
• No effect on Cardio = excellent for HTN

• I onset 2-3
• I duration 30
• Plasma esterases
• laudanosine (seizures) & dec BP

• I onset 1.5-3
• S duration 10-15
• plasma cholinesterase
• dec BP

• I onset 1-3
• L duration 60-100
• 75% renal
• inc BP and inc HR

• S onset 1-2
• L duration 30-60
• liver metab

• Succinylcholine
• S onset .5-1
• S duration 5-10
• plasma cholinesterase
• inc HR, inc BP, Hyperkalemia, fasiculations, myoglobinuria.
• Abn. plasma chE (malignant hyperthermia) = prolonged circulation
• Stimulates Nn

• General anesthetics
• aminoglycosides
• tetracyclines
• Ca++ channel blockers

• phenytoin and carbamazapine
• chronic steroids
• theophylline

Spasmolytic

• dec tone in dysfx muscle while maintaining voluntary control. (MS, stiff mans syndrome)
• GABA a opening leads to hyperpolarization
• dependence tolerance
• TCAD & diazepam = extra depressant on CNS

Spasmolytic

• GABA b receptor leads to no Ca++ into the terminal.
• ALS, intrathecal for spasticity, MS, trigeminal neuralgia, polyafferent neuropathic pain.
• sudden w/d = dysreflexia, breakthrough, ataxia, hallucination

Spasmolytic

Used: MS, ALS, brain & SC disorders ->spasticity

MOA: alpha 2 agonist

Spasmolytic

Used: generaltonic-clonic seizures

MOA: dec Ca+ channel activation presynaptically

Toxicity: somnolence ataxia

• Used: cerebral palsy, hemi & paraplegic pts, malignant hyperthermia****
• neuroleptic malignant syndrome (neuroleptics-haloperidol)
• Serotonin syndrome (MAOI & SSRI)

MOA: interfere with dysfunctional ryanodine receptors

A/E muscle weakness