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Endogenous circannual rhythm
Self generated rhythm that lasts about a year
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Endogenous circadian rhythm
Self generated rhythm that lasts about a day
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Zeitgeber
- Stimulus that resets circadian rhythms
- Ex: Light, tide, noise, temperature..
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Jet lag
Disruption of circadian rhythms due to crossing time zones
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Cortisol
- Adrenal horomone
- Prolonged elevation of cortisol damages neurons in the hippocampus which is important for memory
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Curt Richter
- Introduced idea that the brain generates its own rhythms
- A biological clock
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Suprachiasmatic nucleus (SCN)
- Provides control of circadian rhythms for sleep/temperature
- Damage leaves rhytm inconsistent/no longer synced to light/dark patterns
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Melanopsin
- Photopigment from retinal ganglion cells
- Respond to light even without rods/cones
- Receive input from rods/cones
- See toward the periphery
- Respond to light slowly, turn off slowly when light decreases
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Melatonin
- Released by pineal gland
- Influences circadian/circannual rhythms
- Is secreted at night- makes us sleepy 2-3 hrs before bed
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Coma
- Extended period of unconsciousness
- Steady low level of brain activity
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Vegetative State
- Decreased brain activity
- Periods of sleep/periods of arousal
- Limited responsiveness
- Ex: Increased heart rate to pain
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Minimally Conscious State
- Decreased brain activity
- Brief periods of purposeful actions
- Limited speech comprehension
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Brain Death
- No sign of brain activity for 24+ hours
- No response to any stimulus
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Polysomnograph
EEG + Eye movement records
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Alpha waves
- Rhythm of 8-12 brain waves per second
- Associated with relaxation
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Sleep Spindle
- 12-14 Hz waves during bursts
- Lasts 1/2 second
- Results from interaction between thalamus/cortex cells
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K-Complex
- Sharp high amplitude wave
- Followed by small, slow, positive wave
- Most common in stage 2 of sleep
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Slow-Wave Sleep (SWS)
- Stages 3+4
- Slow, large amplitude brain waves
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Paradoxical Sleep
Deep sleep in some ways, light in others
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Rapid Eye Movement (REM)
- Light
- Paradoxical sleep
- Regular, low voltage fast waves
- Increased neuronal activity
- Deep
- Head muscles are most relaxed
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Pontomesencephalon
- Part of reticular formation
- Contributes to cotrical arousal by axons releasing acetylcholine/glutamate in the basal forebrain/thalamus
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Locus coeruleus
- Dark blue space
- Small structure in the pons
- Inactive most of the time
- Bursts of impulses in response to emotional/meaningful events
- Silent during sleep
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Histamine
- Produced excitation throughout brain
- Cells that release histamine are active during arousal
- Less active around bedtime/early morning
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Orexin
- Peptide neurotransmitter
- Axons release it from basal membrane
- Necessary for staying awake
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Basal forebrain
- Cells provide axons that extend throughout the thalamus/cerebral cortex
- Some release acetylcholine = exictatory/tends to increase arousal
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An increase in GABA..
prevent its axons from spreading stimulation to other areas
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PGO Waves
- REM sleep is associated with a distinctive pattern of high amplitude electrical potentials
- Waves first detected in pons, thalamus, then occipital cortex
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Insomnia
Inadequate sleep
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Sleep apnea
- Impaired ability to breathe while sleeping
- Caused by genetics, hormones..
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Narcolepsy
- Frequent periods of sleepiness during the day
- 1) Sudden attack of sleepiness
- 2) Occasional muscle weakness- cataplexy
- 3) Sleep paralysis
- 4) Hypnagogic hallucinations - dreamlike experiences
- Treatment: Stimulant drugs (Ritalin)
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Periodic Limb Movement Disorder
Repeated involuntary movement of the legs/arms
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REM Behavior Disorder
Move around a lot and act out their dreams
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Night Terrors
- Intense anxiety
- occurr during NREM
- More common in children
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Why do we sleep?
Conserve energy
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Activation-Synthesis Hypothesis
Dream represents the brain's effort to make sense of sparse and distorted information
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Clinicoanatomical hypothesis
Dreams begin with arousing stimuli that are made in the brain combined with recent memories and any info the brain is receiving from the senses
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