-
RB1
retinoblastoma, osteosarcoma
-
VHL
von Hippel-Lindau gene
Clear cell renal carcinoma
-
p53
- chr17p13.1
- mutated 50% tumors
- can inherit mutated allele
- critical gatekeeper: cell cycle arrest and init of apoptosis
- mutated p53 tumors = relatively resistant to chemo/rad
-
APC
chr5q21
APC/B-catenin pathway
familial adenomatous polyps
-
INK4a/ARF
familial melanoma
-
TGFb
colonic carcinoma pt w HNPCC
-
NF-1
neurofibromatosis type 1
GTPase act protein
-
NF-2
Neurofibromatosis type 2
Merlin protein establishes stable cell-to-cell junctions
-
VHL
chr3
Familial/sporadic renal cell CA
-
PTEN
- chr10q23
- endometrial carcinomas, glioblastoma
-
WT-1
chr11p13
Wilms tumor
-
WT-2
Beckwith-Wiedemann syndrome
-
DCC
- chr18q21
- colon, renal carcinomas
-
cadherins
breast, esophagus, colon, ovarian
-
E-cadherin
- somatic- stomach carcinoma
- inher- gastric CA
-
-
BRCA1/2
familial breast,ovarian
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