-
SIS (PBGFP)
PDGFB chain GF
Overexpression
Astrocytoma, osteosarcoma
-
HST1
FGF
Overexpression
Stomach CA
-
INT2 (FGF3)
FGF
Amplication
Bladder, Breast, Melanoma
-
TGFA
TGF-a
Overexpression
- Astrocytoma
- Hepatocelllular carcinoma
-
HGF
HGF
Overexpression
Thyroid CA
-
ERBB1 (EGFR), ERBB2
EGFRs
Overexpression
Squamous cell carcinoma of lung, glioma
-
FLT3
FMS-like Tyr Kinase 3
Amplification
Breast, ovarian CA
-
RET
R for neurotrophic F
Point mutation
Leukemia, endocrine neoplasia 2A/B, familial medullary thyroid carcinomas
-
PDGFRB
PDGF R
Overexpression, translocation
Gliomas, leukemias
-
KIT
R for stem cell F
Point mutation
GI stromal tumors, seminomas, leukemia
-
KRAS
GTP binding
Point mutation
Colon, lung, pancreatic tumors
-
HRAS
GTP binding
Point mutation
Bladder and kidney tumors
-
NRAS
GTP-binding
Point mutation
Melanoma, hematologic malignancies
-
ABL
Nonreceptor tyr kin
Translocation
Chronic yeloid leukemia, acute lymphoblastic leukemia
-
BRAF
RAS signal transduction
Point mutation
Melanoma
-
B-catenin
WNT signal transduction
Point mutation, overexpression
Hepatoblastoma, hepatocellular carcinoma
-
C-MYC
Transcriptional activators
Translocation
Burkitt lymphoma
-
N-MYC
Transcriptional activators
Amplification
Neuroblastoma, small-cell carcinoma of lung
-
L-MYC
Transcriptional activators
Amplification
Small-cell carcinoma of lung
-
Cyclin D
Cyclins
Translocation; amplification
Mantle cell lymphoma; breast and esophageal
-
Cyclin E
Cyclin
Overexpression
Breast
-
CDK4
Cyclin dep kinase
Amplification or point mutation
Glioblastoma, melanoma, sarcoma
-
RET
MEN type IIA,IIB
Familial medullary thyroid carcinoma, Hirschprung disease
-
EGFR
overexpression
Lung tumors, glioblastomas, head and neck tumors
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