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Antagonistic
Acting in opposition; manually opposin
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Electrolytes
Mineral salts (sodium, potassium, and calcium) that carry an electrical charge in solution
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Glucagon
Hormone produced by pancreatic alpha cells that increases the blood glucose level by stimulating the liver to change stored glycogen (a starch form of sugar) to glucose
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Glucose
Simple sugar that is the end product of carbohydrate digestion
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Homeostasis
Relative constancy or balance in the internal environment of the body, maintained by processes of feedback and adjustment in response to external or internal changes
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Hormones
Chemical substances produced by specialized cells of the body that are released slowly in minute amounts directly into the bloodstream
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Insulin
Hormone produced by pancreatic beta cells that acts to remove sugar (glucose) from the blood by promoting its storage in tissues as carbohydrates (glycogen)
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Sympathomimetic
Agent that mimics the effects of the sympathetic nervous system
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Target
Structure, organ, or tissue to which something is directed
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Adrenocorticotropic hormone (ACTH)
- * Adrenal cortex - promotes secretions of some hormones by adrenal cortex, especially cortisol
- * Hyposecretion is rare
- * Hypersecretion causes Cushing disease
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Follicle - stimulating hormone (FSH)
- * Ovaries - in females, stimulates egg production; increases secretion of estrogen
- * Hyposecretion causes failure of sexual maturation
- * Testes - in males, stimulates sperm production
- * Hypersecretion has no known significant effects
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Growth hormone (GH) or somatotropin
- * Bone, cartilage, liver, muscle, and other tissues - stimulates somatic growth; increases use of fats for energy
- * Hyposecretion in children causes pituitary dwarfism
- * Hypersecretion in children causes gigantism; hypersecretion in adults causes acromegaly
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Luteinizing hormone (LH)
- * Ovaries - in females, promotes ovulation; stimulates production of estrogen and prgesterone
- * Testes - in males, promotes secretion of testosterone
- * Hyposecretion causes failure of sexual maturation
- * Hypersecretion has no known significant effects
- * Hyposecretion in nursing mothers causes poor lactation
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Prolactin
- * Breast - in conjunction with other hormones, promotes lactation
- * Hypersecretion in nursing mothers causes galactorrhea
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Thyroid-stimulating hormone (TSH)
- * Thyroid gland - stimulates secretion of thyroid hormone
- * Hyposecretion in infants causes cretinism; hyposecretion in adults causes myxedema
- * Hypersecretion causes Graves disease, indicated by exophthalmos
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Antidiuretic hormone (ADH)
- * Kidney - increases water reabsorption (water returns to the blood)
- * Hyposecretion causes diabetes insipidus
- Hypersecretion causes syndrome of inappropriate antidiuretic hormone (SIADH)
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Oxytocin
- * Uterus - stimulates uterine contractions; initiates labor
- * Breast - promotes milk secretion from the mammary glands
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Calcitonin
- * Regulates calcium levels in the blood in conjunction with parathyroid hormone
- * Secreted when calcium levels in the blood are high in order to maintain homeostasis
- * The most significant effects are exerted in childhood when bones are growing and changing dramatically in mass, size, and shape
- * At best, calcitonin is a weak hypocalcemic agent in adults
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Thyroxine (T4) and triiodothyronine (T3)
- * Increases energy production from all food types
- * Increases rate of protein synthesis
- * Hyposecretion in infants causes cretinism; hyposecretion in adults causes myxedema
- * Hypersecretion causes Graves disease, indicated by exophthalmos
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Parathyroid hormone (PTH)
- * Bones - increases the reabsorption of calcium and phosphate from bone to blood
- * Kidneys - increases calcium absorption and phosphate excretion
- * Small intestine - increases absorption of calcium and phosphate
- * Hyposecretion causes tetany
- * Hypersecretion causes osteitis fibrosa cystica
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Glucocorticoids (mainly cortisol)
- * Body cells - promote gluconeogenesis; regulate metabolism of carbohydrates, proteins, and fats; and help depress inflammatory and immune responses
- * Hyposecretion causes Addison disease
- * Hypersecretion causes Cushing syndrome
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Mineralcorticoids (mainly aldosterone)
- * Kidneys - increase blood levels of sodium and decrease blood levels of potassium in the kidneys
- * Hyposecretion causes Addison disease
- * Hypersecretion causes aldosterone
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Sex hormones (any of the androgens, estrogens, or related steroid hormones) produced by the ovaries, testes, and adrenal cortices
- * In females, possibly responsible for female libido and source of estrogen after menopause (Otherwise, effects in adults are insignificant)
- * Hypersecretion of adrenal androgen in females leads to virilism (development of male characteristics)
- * Hypersecretion of adrenal estrogen and progestin secretion in males leads to feminization (development of feminine characteristics)
- * Hyposecretion has no known significant effects
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Epinephrine and norepinephrine
- * Sympathetic nervous system target organs - hormone effects mimic sympathetic nervous system activation (sypathomimetic), increase metabolic rate and heart rate, and raise blood pressure by promoting vasoconstriction
- * Hyposecretion has no known significant effects
- * Hypersecretion causes prolonged "fight-or-flight" reaction and hypertension
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Glucagon
- * Liver and blood - raise blood glucose level by accelerating conversion of glycogen into glucose in the liver (glycogenolysis) and other nutrients into glucose in the liver (gluconeogenesis) and releasing glucose into blood (glycogen to glucose)
- * Persistently low blood glucose levels (hypoglycemia) may be caused by deficiency in glucagon.
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Insulin
- * Tissue cells - lowers blood glucose level by accelerating glucose transport into cells and the use of that glucose for energy production (glucose to glycogen)
- * Hyposecretion of insulin causes diabetes mellitus
- * Hypersecretion of insulin causes hyperinsulinism
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Adrenomegaly
Enlargement of adrenal glands
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Adrenalectomy
Excision of (one or both) adrenal glands
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Hypercalcemia
Excessive calcium in the blood
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Endocrinology
Study of endocrine glands (and their functions)
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Glucogenesis
Forming or producing glucose
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Hypoglycemia
Abnormally low level of glucose in the blood
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Glycosuria
Abnormal amount of glucose, in the urine
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Homeostasis
State of equilibrium in the internal environment of the body
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Kalemia
Potassium in the blood
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Pancreatotomy
Incision of the pancreas
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Parathyroidectomy
Excision of (one or more of the) parathyroid glands
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Thymoma
Tumor of the thymus gland
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Thyromegaly
Enlargement of the thyroid gland
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Hyperthyroidism
Condition of excessive thyroid gland (function)
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Toxicologist
Specialist in the study of poisons
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Endocrine
Secrete internally or within
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Polydipsia
Excessive thirst
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Androgen
Any steroid hormone that increases masculinization
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Thyrotoxic
Pertaining to toxic activity of the thyroid gland
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Glycosuria
Glucose in the urine
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Euthyroid
Resembling a normal thyroid gland
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Exocrine
Secrete outwardly
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Hyperglycemia
Excessive glucose in the blood
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Hypoinsulinism
Condition of deficiency of insulin
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Polyuria
Excessive urination
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Acromegaly
Chronic metabolic disorder characterized by a gradual, marke enlargement and thickening of the bones of the face and jaw
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Diuresis
Increased formation and secretion of urine
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Glucagon
Hormone secreted by the pancreatic alpha cells
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Glucose
Simple sugar that is the end product of carbohydrate digestion
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Glycosuria
Presence of glucose in the urine or abnormal amount of sugar in the urine
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Graves disease
Multisystem autoimmune disorder characterized by pronounced hyperthyroidism usually associated with enlarged thyroid gland and exophthalmos (abnormal protrusion of the eyeball)
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Hirsutism
Excessive distribution of body hair, especially in women
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Hypercalcemia
Excessive amount of calcium in the blood
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Hyperkalemia
Excessive amount of potassium in the blood
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Hypervolemia
Abnormal increase in the volume of circulating fluid (plasma) in the body
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Hyponatremia
Abnormal condition of low sodium in the blood
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Insulinoma
Tumor of the islets of Langerhans of the pancreas
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Obesity
Excessive accumulation of fat that exceeds the body's skeletal and physical standards, usually an increase of 20 percent or more above ideal body weight
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Morbid obesity
Body mass index (BMI) of 40 or greater, which is generally 100 or more pounds over ideal body weight
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Panhypopituitarism
Total pituitary impairment that brings about a progressive and general loss of hormonal activity
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Pheochromocytoma
Small chromaffin cell tumor, usually located in the adrenal medulla
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Thyroid storm
Crisis of uncontrolled hyperthyroidism caused by the release into the bloodstream of increased amount of thyroid hormone; also called thyroid crisis or thyrotoxic crisis
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Virile
Masculine or having characteristics of a man
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Virilism
Masculinization in a woman or development of male secondary sex characteristics in the woman
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Exophthalmometry
Test that measures the degree of forward displacement of the eyeball (exophthalmos) as seen in Graves disease
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Fasting blood glucose
Test that measures blood glucose levels after 12-hour fast
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Glucose tolerance test (GTT)
Test that measures the body's ability to metabolize carbohydrates by administering a standard dose of glucose and measuring glucose levels in the blood and urine at regular intervals
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Insulin tolerance test
Test that determines insulin levels in serum (blood) by administering insulin and measuring blood glucose levesl in blood at regular intervals
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Protein-bound iodine (PBI)
Test that measures the concentration of thyroxine in a blood sample
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Thyroid function test (TFT)
Test that detects an increase or decrease in thyroid function
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Total calcium
Test that measures calcium to detect bone and parathyroid disorders
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Computed tomography (CT)
Imaging technique that rotates an x-ray emitter around the area to be scanned and measures the intensity of transmitted rays from different angles
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Magnetic resonance imaging (MRI)
Noninvasive imaging technique that uses radio waves and a strong magnetic field rather than an x-ray beam to produce multiplanar cross-sectional images
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Radioactive iodine uptake (RAIU)
Administration of radioactive iodine (RAI) orally or intravenously (IV) as a tracer to test how quickly the thyroid gland takes up (uptake) iodine from the blood
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Thyroid scan
After injection of a radioactive substance, a scanner detects radioactivity and visualizes the thyroid gland
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Microneurosurgery of the pituitary gland
Microdissection of a tumor using a binocular surgical microscope for magnification
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Parathyroidectomy
Excision of one or more of the parathyroid glands, usually to control hyperparathyroidism
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Pinealectomy
Removal of the pineal body
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Thymectomy
Excision of the thymus gland
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Thyroidectomy
Excision of the thyroid gland
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Partial thyroidectomy
Method of choice for removing a fibrous, nodular thyroid
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Subtotal thyroidectomy
Removal of most of the thyroid to relive hyperthyroidism
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Antidiuretics
- Reduce or control excretion of urine
- * Vasopressin
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Antithyroids
- Treat hyperthyroidism by impeding the formation of T3 and T4 hormone
- * Methimazole
- * Strong iodine solution
Administered in preparation for a thyroidectomy and in thyrotoxic crisis
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Corticosteroids
- Replace hormones lost in adrenal insufficiency (Addison's disease)
- * Cortisone
- * Hydrocortisone
Also widely used to suppress inflammation, control allergic reactions, reduce rejection in transplantation, and treat some cancer.
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Growth hormone replacements
- Increase skeletal growth in children and growth hormone deficiencies in adults
- * Somatropin (recombinant)
Increase spinal bone density and help manage growth failure in children.
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Insulins
- Lower blood glucose by promoting its entrance into body cells and converting glucose to glycogen (a starch-storage form of glucose.)
- * Regular insulin
- * NPH insulin
Links with an insulin receptor on the cell membrane, and transports glucose inside the cell where it is metabolized. Type 1 diabetes must always be treated with insulin. Insulin can also be administered through an implanted pump which infuses the drug coninuously. Type 2 diabets that cannot be controlled with oral antidiabetics may require insulin to maintain a normal level of glucose in the blood.
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Oral antidiabetics
- Treat type 2 diabetes mellitus by stimulating the pancreas to produce more insulin and decrease peripheral resistance to insulin.
- * Glipzide
- * Glyburide
Not used to treat type 1 diabetes mellitus
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Thyroid supplements
- Replace or supplement thyroid hormones
- * Levothyroxine
- * Liothyronine
Contains T3, T4, or a combination of both. Also used to treat some types of thyroid cancer.
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ACTH
Adrenocorticotropic hormone
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ADH
Antidiuretic hormone (vasopressin)
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DI
Diabetes insipidus; diagnostic imaging
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DKA
Diabetic ketoacidosis
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FSH
Follicle-stimulating hormone
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HRT
Hormone replacement therapy
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K
Potassium (electrolyte)
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mg/dl, mg/dL
Milligrams per deciliter
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MSH
Melanocyte-stimulating hormone
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NPH
Neutral protamine Hagedorn (insulin)
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PGH
Pituitary growth hormone
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PTH
Parathyroid hormone; also called parathormone
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RAIU
Radioactive iodine uptake
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T3
Triiodothyronine (thyroid hormone)
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T4
Thyroxine (thyroid hormone)
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TFT
Thyroid function test
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TSH
Thyroid-stimulating hormone
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