-
SIS
- Growth Factor
- - Astrocytoma, gliocytoma/blastoma
-
-
EGFR (ERB B1)
- SIS Receptor
- Head, Neck, Lung carcinoma
-
Her2Neu (ERB B2)
- HST receptor
- Breast Carcinoma
-
TGF-Beta
- Receptor
- Colon & Pancreatic cancer
-
VHL
- Suppressor
- -Von-hippel lindau disease
- -clear cell renal carcinoma
- -cavernous hemangioma
-
Cadherin
- adherance factor
- Breast & Visceral cancer
-
PTEN
- PI3 pathway
- Endometrial carcinoma
-
RAS
- Transducer
- Adenocarcinoma (colon & Pancreas)
-
NF-1
- Transducer
- Neurofibromatosis
-
-
APC/Beta-catenin
- Familal Adenomatous polyposus
- Colon adenomatous carcinoma
-
BCL-2
- Adhesion evader
- B-cell follicular lymphoma
-
MYC
- Transcription
- Burkitt's lymphoma
-
N-MYC
- Transcription
- Neuroblastoma
-
INK-4
- Transcription inhibitor
- Familial melanoma & HPV
-
RB
- Transcription
- Retinoblastoma, Osteosarcoma, HPV
-
NER
- Transcription
- Xeroderma pigmentosa
-
Mismatch repair (MLH,MSH)
hereditary Non-polyp colon cancer (HNPCC)
-
BRCA-1&2
- Transcription
- Breast & Ovarian cancer
-
ATM
- Transcription
- Ataxia telangiectasia
-
P53
- Transcription
- **All cancers
- Li Fraumeni familial cancer
-
Cyclin D/CDK-4
- breast cancer
- glioblastoma
- melanoma
-
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