pharm-HTN

- Diuretics

- Sympathoplegics

- Vasodilators

- Angiotensin antagonists

- Chlorothiazide

- Furosemide

- Spironolactone

- Mannitol

• - diuretic drug for hypertension
• - @ DCT - inhibits Na/Cl symporter --> retains Na - H2O --> excretion
• - toxicity: hypokalemia

- Diuretic drug for HTN

- @ loop of henle (ascending limb)

- Na/K/Cl symporter, Ca excretion -> retains ions -> H2O -> excretion

- Toxicity : hypokalemia

- Diuretic drug for HTN

- @ CT – aldosterone antagonist

- Retains Na&H2O à excretion

- Toxicity: HYPERkalemia

- Diuretic drug for HTN

• - @ loop of Henle (descending limb) –
• osmotic agent

- inhibits H2O reabsorption -> excretion

- Toxicity: hyponatremia, hyperkalemia

- Clonidine(a2 agonist)

- Reserpine

- Nicotinic R blocker

- Prazosin (a1 blocker)

- Propanolol (b1 blocker)

-sympathoplegic drug for HTN

-a-2 agonist

- sympathoplegic drug for HTN

- inhibits MA packaging and release

- sympathoplegic drug for HTN

- b-blocker --> heart --> inhibits contraction

- sympathoplegic drug for HTN

- a1 blocker --> arterioles

- nitrovasodilators (hydralazine)

- k-channel agonists (hyperpolarizes cell --> inhibits contraction)

- L-type Ca Channel blockers (verapamil, diltiazem, nifedipine)

- vasodilator (HTN)

- inhibits GC --> relaxes vasc SM --> dec peripheral R

- ACEi - captopril ("-pril")

- ARB - losartan ("-tan")