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What are the inhibitors and activators of Fructose-6-Phosphate going to Fructose-1,6-Phosphate
- Phosphofructokinase
- Stimulating Glycolysis
- + Fructose-2,6-Phosphate
- + AMP
- - Citrate
- - H+
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What are the inhibitors and activators of Fructose-1,6-Phosphate going to Fructose-6-Phosphate?
- Fructose-1,6-Bisphosphatase
- Stimulating glyconeogenesis
- - Fructose-2,6-Phosphate
- + ATP
- + Citrate
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PKA is activated by:
Glucagon, low blood glucose levels
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What activates FBPase2?
PKA
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What happens when FBPase is activated?
- Glycolysis is inhibited
- Gluconeogenesis stimulated
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What activates PFK2?
Phosphoprotein phosphate
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What happens when PFK2 is activated?
- Glycolysis stimulated
- Gluconeogensis inhibited
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What are the enzymes involved in pyruvate dehydrogenase?
- Pyruvate dehydrogenase component (TPP)
- Dihydrolipoyl transacteylase (Lipoic Acid)
- Dihydrolipoyl dehydrogenase form (FAD)
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What does pyruvate bind to in PDH?
Binds to TPP and kicks of an CO2 to form TDP-OH-CH3
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When the acetyl group is bound to TDP where does it goes next?
- Breaks the disulfide bond in Lipoic acid to form
- SH
- S-C=O,-CH3
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What is the next step in PDH when the acetyl group is bound to lipoic acid?
CoA-SH steels the Acetyl group to make Acetyl CoA
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After the acetyl group is stolen from Lipoic Acid what is the next step in PDH?
- The disulfide bound needs to be oxidized to be regenerated which is by E3's FAD
- Then NAD+ oxidizes FADH2 to FAD+ to reset everything in the enzyme
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What are the enzymes of the inner mitochondria?
- Electron Carriers (Complexes I-IV)
- ATP synthase
- Membrane transporter
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What are the enzymes of the mitochondrial matrix?
- Citric Acid cycle enzymes
- Beta oxidation enzymes
- Pyruvate Dehydrogenase
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What are the enzymes of the outer mitochondria membrane?
- Acyl CoA synthetase
- Glycerolphosphate acyl transfrerase
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