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Mecasermin
Tx?
A/E?
MOA?
- Mecasermin (rIGF-1; TARGET TISSUE)
- Tx: Laron syndrome (mutated GH-R or Ab to GH-R)
- A/E:Hypoglycemia (administor W/snack)
- MOA:give W/RIGF BP-3 clasts longer)
- -short statue due IGF-I deficiency w/high GH;IGF-1
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Sermorelin
MOA?
TX?
- MOA:GHRF
- TX:Diagnostic,GH def, weight loss in AIDS,lack of GHRH/F
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Octreotide
TX?
A/E?
ADMIN?
- TX:GH overactivity-acromegaly
- -supress ectopic hormone production by tumors
- -45x more potent than somatostatin
- Admin SC(3x/day),IM(1x/mo)
- A/E: GI side effects;Vit B12 def.conevery tissue responsive somatostatin
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