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ANTI-INFLAMMATORY DRUGS
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Nonsteroidal Anti-Inflammatory Drugs (6)
1) Salicylates
2) Propionic Acid Derivatives
3) Acetic Acid Derivatives
4) Indole Derivatives
5) Oxicams
6) Coxibs
Salicylates
1) Aspirin
2) Sulfasalazine
Propionic Acid Derivatives
1) Flurbiprofen
2) Ibuprofen
3) Naproxen
4) Oxaprozin
Acetic Acid Derivatives
1) Diclofenac
2) Ketorolac
3) Sulindac
Indole Derivatives
Indomethacin
Oxicams
1) Meloxicam
2) Piroxicam
Coxibs
Celecoxib
Analgesic- Antipyretic Drugs
Acetaminophen
Short- to - medium acting Glucocorticoids
1) Cortisone
2) Hydrocortisone
3) Methylprednisolone
4) Prednisolone
5) Prednisone
Intermediate- Acting Glucocorticoids
Triamcinolone
Long-acting Glucocorticoids
1) Betamethasone
2) Dexamethasone
NSAIDS MOA
COX 1 & COX 2 reversible inhibition
Anti-inflammatory
Analgesic
Antipyretic
Aspirin (Clinical & contra)
NSAID - Salicylate
irreversible COX inhibitor
Clinical
: (80-325 = anti-platelet) (300-600 = analgesic) (1000 = anti-inflammatory)
thromboembolic
CONTRA
: pregnancy
GI problems
nephropathy
Reyes Syndrome
Sulfasalazine
NSAID- Salicylate
COX and LOX inhibitor
Clinical: Crohns & ulcerative colitis
Ibuprofen
NSAID- Propionic Acid Derivative
Clinical
:
close ductus arteriosas
children with viral fever
Ketorolac
NSAID- Acetic Acid Derviative
Clinical
:
powerful analgesic (dec opioid requirement)
inflammatory condition with the eye
A/E: Increased renal toxicity
Indomethacin
NSAID - Indole Derivative
MOA
:
inhibits phospholipase A& C
dec neutrophil migration, and B & T cell proliferation
Meloxicam
NSAID - Oxicam
MOA
: COX 2 inhibitor
Clinical
: osteoarthritis
Celecoxib
NSAID - Coxib
Fewer GI problems
BLACK BOX b/c cardiac problems
Contra
:
warfarin (potentiation)
pregnancy (inhibits labor)
Acetaminophen
Analgesic-Antipyretic
Not anti-inflammatory
MOA
: COX 1 & COX 2 Centrally only
A/E
: NAPQ1 (glutathione)
Treat with Charcoal or NAC
Alcohol induces CYP450 -> more NAPQ1
Dexamethasone
Long- acting Glucocorticoid
Clinical
: diagnosis of Cushings
Treatment of Renal dysfunction
Piroxicam
Oxicam
MOA:
Nonselective COX inhibitor
inhibits PMN leukocyte migration (high doses)
dec Oxygen radical species (high)
Inhibits lymphocyte fx (high)
A/E: inc incidence of peptic ulcer and bleeding (high doses)
Author
lazzsant
ID
109300
Card Set
ANTI-INFLAMMATORY DRUGS
Description
ANTI_INFLAMMATORY
Updated
2011-10-24T21:33:50Z
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