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Clozapine
- - atypical antipsychotic
- - block D2Rs w/ less affinity than 1st gen
- - less affinity therefore less EPS
- also found to block 5HT system
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Chloropromazine
- - phenylthiazine
- - 1st generatino antipsychotic
- - targets DA-Rs (DA antagonist)
-
2 Anti-psychotic drugs
chlorpromazine, clozapine
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Reserpine
- = depressant
- - prevent packaging of DA & NA into vesicles, therefore inhibit their release
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Functions of:
1. MAOi
2. TCAs
3. SSRIs
- 1. MAOi --> inhibit NA, 5HT breakdown
- 2. TCAs --> inhibit NA, 5HT reuptake
- 3. SSRIs --> inhibit 5HT reuptake
==> increase [NA & 5HT] in synapse
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Fluoxetine
- = prozac
- - SSRI --> inhibits SERT
-
-
Imipramine
- - TCA
- - inhibits NAT --> therefore increases [NA] in synapse
- can also inhibit SERT
-
Tyramine
What happens when MAOi's are added?
What is cheese effect?
- - causes release of stored MAs
- - can lead to hypertensive crisis
- - normally degraded by MAO
- - accumulation of tyramine --> crosses BBB --> activates sympathetic NS
- - MAOi also inhibits NA degradation
- - therefore get exacerbated increase in sympathetic system
- cheese effect --> cheese has lots of tyramine
-
MAO
- function
- types
- - breaks down monoamines: 5-HT, NA, DA
- - MAO-A: found in CNS, liver, GI, placenta
- - MAO-B: found in platelets
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Isoniazid
- - 1st anti-depressant
- - removed b/c caused hepatitis
- - MAOi
-
Name some Antidepressants
Name a Depressant
- Isoniazid - 1st anti-depressant
- Fluoxetine (aka Prozac) (SSRI)
- Phenelizine (MAOi)
- Imipramine (TCA)
Reserpine
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