Ch. 6 Neuro Terms

  1. cholinergic
    neorons or synapses that produce and release ACh
  2. noradrenergic
    neurons or synapses that produce and release norepinephrine
  3. glutamatergic
    neurons or synapses that produce and release glutamate
  4. GABAergic
    neurons or synapses that produce and release gamma-aminobutyric acid
  5. peptidergic
    neurons or synapses that produce and release peptide neurotransmitters
  6. immunocytochemistry
    an anatomical method that uses antibodies to study the location of molecules within cells
  7. in situ hybridization
    a method for localizing strands of messenger RNA within cells
  8. autoradiography
    method for visualizing sites of radioactive emissions in tisssue sections
  9. microionophoresis
    method of applying drugs and neurotransmitters in very small quantities to cells
  10. receptor subtype
    one of several receptors to which a neutro transmitter binds
  11. nicotinic ACh receptor
    a class of acetylcholine-gated ion channel found in various locations (mainly at the neuromuscular junction)
  12. muscarinic ACh receptor
    a subtype of acetylcholine receptor that is a G-protein-coupled
  13. AMPA receptor
    a subtype of glutamate receptor; a glutamate-gated ion channel that is permeable to Na+ and k+
  14. NMDA receptor
    a subtype of glutamate receptor; a glutamate-gated ion channel that is permeable to Na+, K+, and Ca+. Inward ionic current through the N-methyl-d-aspartate receptor is voltage dependent bc of a magnesium block at neg. membrane potentials.
  15. kainate receptor
    a subtype of of glutamate receptor; a glutamate gated-ion channel that is permeable to Na+ and K+
  16. ligand binding method
    method that uses radioactive receptor ligands (agonists or antagonists) to locate neurotransmitter receptors
  17. Dale's Principle
    idea that a neuron has a unique identity with respect to neurontransmitter
  18. co-transmitter
    one of two or more different neurotransmitters that are released from a single presynaptic nerve terminal
  19. acetylcholine (ACh)
    an amine that serves as a neurotransmitter at many synapses in the peripheral and central nervous systems, including the neuromuscular junction
  20. transporter
    a membrane protein that transports neurotransmitters, or their precursors, across membranes to concentrate them in either presynaptic cytosol or synaptic vessels
  21. rate limiting step
    in the series of biochemical reactions that leads to the production of a chemical, the one step that limits the rate of synthesis
  22. catecholamines
    neurotransmitters dopamine, norepinephrine, and epinephrine
  23. dopamine
    a catecholamine neurotransmitter synthesized from dopa
  24. norepinephrine (NE)
    catecholamine neurotransmitter synthesized from dopamine; aka noradrenaline
  25. epinephrine (adrenaline)
    a catecholamine neurotransmitter synthesized from norepinephrine; aka adrenaline
  26. dopa
    chemical precursor of dopamine and the other catecholamines
  27. serotinin (5-HT)
    an amine neurotransmitter, 5 hydroxytryptamine
  28. serotonergic
    desrcrining neurons or synapses that produce and release serotonin
  29. glutamate (glu)
    an amino acid; the major excitory neurotransmitter in the CNS
  30. glycine (gly)
    an amino acid; an inhibitory neurotransmitter at some locations in the CNS
  31. gamma-aminobutyric acid (GABA)
    amino acid synthesized from glutamate; the major inhibitory neurotransmitter in the CNS
  32. endocannabinoid
    a natural (endogenous) chemical that binds to, and activates, cannabinoid (CB) receptors
  33. retrograde messenger
    any chemical messenger that communicates info from the postsynaptic side foa synapse to the presynaptic side
  34. nitric oxide (NO)
    a gas produced from the amino acid arginine that serves as an intercellular messenger
  35. benzodiazepine
    a class of drugs with antianxiety, sedative, muscle-relaxing, and anticonvulsant effects; acts by binding to GABAA receptors and prolonging their inhibitory actions
  36. barbiturate
    a class of drugs with sedative , general anesthetic , and anticonvulsant effects; barbituates act in part by binding to GABAA receptors and proloning their inhibitory
  37. second messenger cascade
    a multistep process that couples activation of a neurotransmitter receptor to activation of intracellular enzymes
  38. protein kinase A (PKA)
    a protein kinase activated by the second messeger cAMP
  39. phospholipase C (PLC)
    an enzyme that cleaves the membrane phospholipid phospatidylinositol-4-5-biphosphate to form the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3)
  40. diacylglycerol (DAG)
    second messenger molecule formed by the action of phospholipase C on the membrane phospholipid phosphatidylinositol-4-5-biphosphate. it activates the enzyme protein kinase C
  41. inositol-1-4-5-triphosphate (IP3)
    second messenger molecule formed by the action of phospholipase C on the membrane phospholipid phosphatidylinositol-4-5-bisphosphate. IP3 causes the release of Ca2+ from intracellular stores
  42. protein kinase C (PKC)
    a protein kinase activated by the second messenger DAG
  43. calcium-calmodulin-dependent protein kinase (CaMK)
    a protein kinase activated by the elevations of internal Ca2+ concentration
  44. protein phosphatase
    an enzyme that removes phosphate groups from proteins
Author
princessmagonda
ID
109115
Card Set
Ch. 6 Neuro Terms
Description
Vocab
Updated