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Identify the average range for adult blood volume?
4-6 L
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What are the functions of the cardiovascular system (blood)?
- A. transports
- B. temp. maintenance
- C. fluid balance
- D. acid-base balance
- E. hemostasis
- F. resistance
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Define plasma?
fluid portion of unclotted whole blood
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Define serum?
fluid portion of clotted whole blood
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Define erythrocyte?
red blood cells
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Define leukocyte?
white blood cells
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Define thrombocyte?
platelets
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What is the function of erythrocytes?
transport O2 (hemoglobin)
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What is the function of neutrophils?
phagotype > promotes inflamation
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What is the function of eosinophils?
phagotype > anti-inflamatory
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What is the function of basophils?
phagotype > inflamatory
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What are the functions of momocytes/macrophages?
phagocytosis, immunity, inflamatory
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What is the function of lymphocytes?
immunity
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What is the function of thrombocytes?
hemostasis
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Define erythropoiesis?
RBC production
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Outline erythropoieses's regulation?
hypoxia > kidney > erythropoietin > red marrow > RBCs
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What are the required dietary factors of erythrocytes?
- 1. nutritional- iron, amino acids, folic acids, B12
- 2. intrinsic factor- made by stomach B12- absorption (sm int.)
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Where is intrinsic factor produced and what is it's function?
stomach, B12 absorption (sm int.)
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What are the blood types of the ABO group?
A, B, AB, O
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Which antigens and antibodies are associated with each type?
- A > A, anti B
- B > B, anti A
- AB > both antigens, no antibodies
- O > no antigens, both antibodies
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What is unique about ABO group antibodies?
naturally occuring
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What is responsible for most transfusion reactions?
recipient's antibodies targeting donor's antigens
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Identify the universal donor and recipient and explain why each qualifies?
- O-, no RBC antigens to be targeted
- AB+, no antibodies to target RBCs
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How are people classified with regard to the Rh D antigen?
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Outline the general setting in which antibodies against the Rh D antigen would produce?
antibodies can be formed by a Rh neg person if exposed to Rh D antigens on the RBCs of a Rh+ person
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Define hemostasis?
stoppage and bleeding
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List the sequence of events involved in hemostasis?
- 1. vascular spasm
- 2. platelet plug
- 3. coagulation
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Define coagulation?
cascading series of reactions d/t clotting factors > fibrin clot
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