chp 3

BENZODIAZEPINES-binds to GABA receptors. its also used as an anticonvulsant.they interfear with motor ability,attention and judgement.(DIAZEPAM CLONAZEPAM ALPRAZOLAM)

BUSPIRONE-reduces anxiety without strong sedative-hypnotic efffects.

deficiency of NOREPINEPHRINE or SERATONIN or both in the limbic system

TRICYCLIC ANTIDEPRESSANT(TCA)-acts primarily by blocking reuptake of norepinephrine(AMITRIPTYLINE IMIPRINE NORTRIPTYLINE)

SELECTIVE SEROTONON REUPTAKE INHIBITORS(SSRI)-block reuptake of serotonin.they take upto 3-6 weeks to function.(CELEXA ZOLOFT PAXIL)

MONOAMINE OXIDASE INHIBITORS(MOI)-act by inhibiting the enzyme MAO, interferring w/ destruction of neurotransmitter monoamine.(phenelzine tranylcypromine)

LITHIUM-affects electrical conductivity in neurons. it may interact with sodium/potassium at the cell membrane to stabilize conductivity. it has A LOW THERAPEUTIC INDEX.(DOSE 0.8-1.5)

ANTICONVULSANTS-reduces mood swings in bipolar pts. (drugs: CARBAMAZAPINE(TEGROL)-DEPAKOTE-CLONAZEPAM(KLONOPIN)

• DEPAKOTE(VALPROATE)-IT IS EFFECTIVE IN TREATING MANIC DEPRESSION.
• CARBAMAZEPINE(TEGROL)-IT TREATS UNIPOLAR DEPRESSION.
• CLONAZEPAM(KLONOPIN)-ITS STRUCTURALY A BENZODIZEPINE, A TYPE OF ANTIANXIETY MED. IT HAS STRONG SEDATING PROPERTIES.PT DEVELOP TOLERANCE AND DEPENDENCE.

• these drugs are stong antagonist of dopamine. treats positive symp. of schitzopherenia(delusions/hallucinations)
• causes-involuntary motor movement.(parkinsonism)orthostatic hypotension,weight gain.(THIOXANTHENES PHENOTHIAZINES)

• these cause few to no extrapyramidal symptoms. treatsnegative and positive symptoms. they are also antagonist for serotonin receptors.
• CLOZAPINE- MAY INDUCE AGRONULOCYTOSIS NOT THE 1ST LINE USAGE.
• RISPERIDONE-REDUCES HALLUCINATIONS AND DELUSIONS AND CAUSES ORTHOSTATIC HYPOTENSION.
• QUETIAPINE-BROAD RECEPTOR BINDING PROFILE. PRODUCES SEDATION AND WEIGHT GAIN

NEUROTRANSMITTER(HAPPY)

refers to the action of drug on the person

refers to the action of the person on the drug( absorption,excretion, etc)