drugs

Influenza A tx|Inhibits viral uncoating

Influenza tx|Oral nuraminidase inhibitor (sialic acid analog, inhibits virion release)

Influenza tx|Inhaled nuraminidase inhibitor (sialic acid analog)

Herpesvirus tx|Nucleoside analog

Herpesvirus tx|Acyclovir prodrug (nucleoside analog for viral thymidine kinase)

Herpesvirus tx|Penciclovir prodrug (nucleoside analog)

Herpesvirus, CMV tx|IV nucleoside analog for viral thymidine kinase

Herpesvirus, CMV tx|Oral, ganciclovir prodrug (nucleoside analog for viral thymidine kinase)

Hep C, RSV tx, experimental RNA virus tx|Sythetic guanosine analogue (interferes w/ txn)

Strep, Syphilis, Spirochete tx|Natural penicillin, highly susceptible to Beta lactams

Strep, Syphilis, Spirochete tx (gram +)|Natural penicillin, highly susceptible to Beta lactams

Enhanced gram (-) coverage, listeria/H. influenzae tx

GI & resp tract gram (-) tx|IV formulation

Enhanced gram (-) coverage, Group A strep tx

Active against most respiratory and some GI gram (-), staph|PO

Gram (+) tx|More stable to Beta-lactamases (IV)

Gram (+) tx|More stable to Beta-lactamases (IV)

Gram (+) tx|More stable to Beta-lactamases (PO)

Enhanced gram (-) coverage|(IV)

GI & resp tract gram (-), pesudomonas aeruginosa tx|(IV)

Very broad specturm (MSSA, pseudomonas, anaerobics)|Seizure risk

Broad spectrum, no pseudomonas activity|(IV qd)

Good gram (+), limited gram (-), MRSA tx|(IV)

Good gram (+), limited gram (-), MRSA tx|(PO)

Good gram (+), moderate gram (-), CA-pneumococcus/H. influenzae tx|(PO)

Good gram (+), moderate gram (-), some anaerobic |(IV)

S. aureus, gonorrhea, gram (-) tx|(IV/IM)

No gram (+), Pseudomonas tx|(IV)

Gonorrhea, tonsilitis, pharyngitis tx|(PO)

Broad-spectrum, good-tasting (used for peds)

Very good gram (+), S. aureus, good gram (-), P. aeruginosa tx|(IV)

Gram (+) & gram (-) tx|Trimethoprim inhibits bacteria dyhydrofolate reductase|Sulfonamides inhibits PABA & pteridine

Broad activity vs gram (+), 1st line tx vs MRSA|Interrupts cell wall crosslinking|Tox: Red Man Syndrome

Very broad spectrum (STD, pneumonia, malaria prophylaxis)|Bind to 30s subunit to inhibit tRNA binding to A site|Not used in children (stains teeth)

Broad spectrum, good Gm (-)|Billiary excretion

Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)

Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)

Aerobic gram (-) tx, some staph/strep|Disrupts electrochem gradient (aerobic only)

Active vs chlamydia, rickettsia, mycoplasma, legionella gram (+)|Bacteriostatic (bind 50s subunit)|More GI upset, more freq dosing, lesser spectrum than other macrolides, (IV & PO)

Active vs chlamydia, rickettsia, gram (+), highly active vs mycoplasma,|Bacteriostatic (bind 50s subunit)|Only PO

Active vs chlamydia, rickettsia, gram (+), highly active vs mycoplasma|Bacteriostatic (bind 50s subunit)|Longer t1/2, no hepatic metabolism, compared to other macrolides, (IV & PO)

Active vs gram (+), staph, & anaerobes|Protein synth inhibitor

S. aureus/MRSA, strep, enerococcus faecium/faecalis,VRE tx|Protein synth inhibitor|Weak MAOI -> serotonin syndrome w/SSRIs

Active against many gram (+), MRSA, VRE |Not for pneumonia (inactivated by surfactant)|Inserts K+ channel into gram (+) & disrupts electrochem gradient

Active vs gram (+), mycobacteria|Inhibits mRNA synth|(PO, IV)

Highly bactericidal for anaerobic bact (no activity vs gm +/-, aerobic), protozoan tx|e- acceptor that damages DNA

Gram (-), Pseudomonas, GI/UTI infection tx|Interacts with DNA gyrase|(IV,PO)

Active vs gram (+), gram (-) |Pure S isomer of ofloxacin|Interacts w/ DNA gyrase, topoisomerase|(IV, PO)

Used only for UTIs (only active in bladder)

TB tx|Hepatotoxicity risk in slow acetylators

TB, TB meningitis tx|Part of multidrug tx

Bacteriostatic anti-TB drug|Part of multidrug tx

Most broad-spectrum anti-fungal|Forms channel in fungal membrane -> loss of cations|Nephortoxicity w/ >2wks use, lipid formulation much safer

Topical polyene antifungal (disrupts cell wall)|Too nephrotoxic for systemic use

Active vs most cryptococcus, candida|14 alph-demethylase inhibitor -> prevents ergosterol synth

Candida, invasive aspergillosis tx|14 alph-demethylase inhibitor -> prevents ergosterol synth|(PO & IV)

Active vs most candida, most aspergillus, many molds|PO only

2nd line aspergillus tx|Beta 1,3 D glucan synth inhibitor -> interferes with cell wall synth|(IV)

Onychomycosis, tinea tx, adjunctive for severe mold|Inhibits squalene epoxidase step in ergosterol biosynth

Malaria tx|Inhibits polymerization of hemozoin in plasmodium food vacuole|PO

Later-gen quinacrine malaria tx|Weekly dosing

Anti-malarial|Inhibits mitochondial ETC/DHFR

Anti-malarial

Anti-helminthic tx|Inhibits tubuline polymerization/MT formation in worms

Anti-helminthic tx|Inhibits tubuline polymerization/MT formation in worms

Scistsomiasis, clonorchiasis, & other fluke tx

Nitrogen mustard alkylating agent -> cross links DNA|Toxicity: Hemorrhagic cystitis

Platinum-containing anti-cancer agent |Toxicity: Neuropathy, hearing loss, kidney damage, emetogenic

Platinum-containing anti-cancer agent|Toxicity: neuropathy

Plant alkyloid used for ALL, Hodgkins, NHL|Severe toxicity to lymphoid cells (blocks MTs)

Plant alkyloid used for ALL, Hodgkins, NHL|Severe toxicity to lymphoid cells (blocks MTs)

Dihydrofolate reductase inhibitor (anti-folate)|Leucovorin antidote rescues non-cancer marrow cells

Thymidylate synthase inhibitor used for GI malignancy

Breast cancer tx|Binds estrogen receptor

Antineoplastic antibiotic from Streptomyces|Intercalate between DNA strands, chelation, topoisomerase inhibition|Toxicity: cardio, alopecia, myelosuppression

CML tx|Bcr-abl tyrosine kinase inhibitor

APL tx|Induces differentiation

Anti-CD20 chimeric Ab (anti-Bcell) used for leukemia/lymphoma

Anticoagulant |Vitamin K antagonist

Anticoagulant|Inactivates thrombin & Fxa