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MED-Diazepam
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Functional Class
Benzodiazepine
Mechanism of Action
Intensifies the activity of GABA- suppreses seizure activity in the motor cortex of the brain
Effective with stress, anxiety and alcohol withdrawal due to its sedative effects
Effective as pre-medication for painful orthopaedic procedures due to skeletal muscle relaxant effects
Effective as pre-medication for cardioversion due to its amnesia effects
Indications
Seizures (Status epilepticus)
To induce sedation prior to painful procedures
Acute anxiety
Contraindications
Known hypersensitivity to the drug
Shock
Coma
Acute alcohol intoxication
Precautions
Can cause local irritation at IV site. Use large vein when possible.
Seizure activity may reoccur due to its lipid solubility
Use caution in patients with myasthenia gravis, impaired renal or hepatic function, obstetrical patients and elderly
Side Effects
Hypotension
Drowsiness
Tachycardia
Ataxia
Amnesia
Slurred speech
Edema
Headache
Dizziness
N/V
Blurred vision
Respiratory depression
Interactions
Effects enhanced when used in conjuction with other CNS depressants and alcohol
Cimetidine may increase diazepam plasma levels
Dosage and Route
ADULT
IVP
5 mg, may repeat at 2.5 mg every 5 minutes prn, max 10 mg
PEDI
IV/IO
0.1-0.25 mg/kg, max single dose 5 mg
Rectal (PR)
0.5 mg/kg, max single dose 10 mg, may repeat once after 5 mins
Pharmacokinetics
Onset = 1-5 mins IV
Half-life = 20-50 hours
Note
Flumazenil is an antagonist to diazepam
Author
amerelman
ID
10799
Card Set
MED-Diazepam
Description
MED-Diazepam
Updated
2010-03-16T16:02:33Z
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