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What drugs or food have the potential to interact with the centrally acting nonopioid drug tramadol (Ultram)?
- Monoamine oxidase inhibitors (MAOIs) pose a risk for hypertensive crisis.
- Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, MAOIs, and triptans pose a risk for serotonin syndrome.
- Responses to CNS depressants increase.
- Carbamazepine (Tegretol) decreases levels.
- St. John's wort increases sedative effects.
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What drugs or food have the potential to interact with the glucocorticoid drug prednisone (Deltasone)?
- Potassium-depleting diuretics, such as furosemide (Lasix), increase the risk of hypokalemia.
- The risk of digoxin-induced dysrhythmias increases with digoxin.
- NSAIDs increase the risk of gastrointestinal bleeding and ulceration.
- Effects of insulin and oral hypoglycemics decrease in a patient who has diabetes mellitus.
- Prednisone prevents the body from responding to vaccines.
- Live vaccine administration increases risk for developing that viral disease
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What drugs or food have the potential to interact with the uricosuric drug allopurinol (Zyloprim)?
- Warfarin (Coumadin) requires lower dosages.
- The risk of mercaptopurine (Purinethol), theophylline (Theolair), and azathioprine (Imuran) toxicity increases.
- Ampicillin (Principen) increases the risk for rash.
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What drugs or food have the potential to interact with the NSAID (COX-2 inhibitor) celecoxib (Celebrex)?
- Diuretic effects of furosemide (Lasix) decrease.
- Fluconazole (Diflucan) increases celecoxib levels.
- Anticoagulant effects of warfarin (Coumadin) increase.
- Glucocorticoids and alcohol increase the risk of bleeding.
- Antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitors decrease.
- The risk of lithium carbonate (Eskalith) toxicity increases.
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What drugs or food have the potential to interact with the opioid agonist drugs morphine and meperidine (Demerol)?
- CNS depressants (barbiturates, phenobarbital, benzodiazepines, alcohol) increase CNS depression.
- Anticholinergic agents, such as antihistamines, and tricyclic antidepressants increase anticholinergic effects (constipation, urinary retention).
- MAOIs can cause hyperpyrexic coma (excitation, seizures, respiratory depression) with meperidine (Demerol).
- Antihypertensives increase hypotensive effects.
- St. John's wort may increase sedation.
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What drugs or food have the potential to interact with the drug acetaminophen (Tylenol)?
- Alcohol increases the risk of liver injury (with high doses of acetaminophen).
- Warfarin (Coumadin) increases the risk of bleeding.
- Cholestyramine (Questran) reduces absorption.
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What drugs or food have the potential to interact with the opioid antagonist drug naloxone (Narcan)?
Opioid effects decrease.
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What drugs or food have the potential to interact with the NSAIDs (COX-1 and COX-2 inhibitors) aspirin/acetylsalicylic acid (Aspirin) and ibuprofen (Advil, Motrin)?
- Anticoagulants, glucocorticoids, and alcohol increase the risk of bleeding.
- Ibuprofen decreases the antiplatelet effects of low-dose aspirin.
- Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers increase the risk of renal failure.
- ACE inhibitors decrease.
- The risk of lithium carbonate (Eskalith) and methotrexate (Rheumatrex) toxicity increases.
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What drugs or food have the potential to interact with the opioid agonist-antagonist drugs butorphanol (Stadol) and pentazocine (Talwin)?
- Central nervous system (CNS) depressants (barbiturates, phenobarbital, benzodiazepines, alcohol) increase CNS depression and increase the risk of respiratory depression.
- Opioid effects decrease.
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