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What are some contraindications that would make taking the NSAIDs (COX-1 and COX-2 inhibitors) aspirin/acetylsalicylic acid (Aspirin) and ibuprofen (Advil, Motrin) risky for the patient?
- Pregnancy (risk category D)
- Hypersensitivity to aspirin and other NSAIDs
- Peptic ulcer disease
- Bleeding disorders (hemophilia, vitamin K deficiency)
- Child or adolescent with chickenpox or influenza (especially aspirin)
- Perioperative use prior to coronary artery bypass grafting (non-aspirin NSAIDs)
- Within 1 week of any elective surgery (aspirin)
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What are some contraindications that would make taking the NSAID (COX-2 inhibitor) celecoxib (Celebrex) risky for the patient?
- Pregnancy (risk category D [third trimester]; C in first and second trimesters); can cause premature closure of the ductus arteriosus
- Severe hepatic impairment
- Advanced renal disease
- Child or adolescent younger than 18 years old
- Gastrointestinal bleeding
- Anemia
- Pain from coronary artery bypass grafting
- Allergy to sulfa, sulfonamides, celecoxib
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What are some contraindications that would make taking the opioid agonist-antagonist drugs butorphanol (Stadol) and pentazocine (Talwin) risky for the patient?
- Acute myocardial infarction
- Opioid dependence
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What is a contraindication that would make taking the drug acetaminophen (Tylenol) risky for the patient?
Alcoholism
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What are some contraindications that would make taking the opioid agonist drugs, morphine and meperidine (Demerol) risky for the patient?
- Pregnancy risk category D (long-term use, high doses, near term; otherwise C)
- Renal failure
- Increased intracranial pressure
- Biliary colic
- Preterm labor
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What are some contraindications that would make taking the centrally acting nonopioid drug tramadol (Ultram) risky for the patient?
- Acute intoxication with alcohol, opioids, psychotropic drugs
- Seizure disorders
- Respiratory depression
- Child or adolescent younger than 16 years old
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What are some contraindications that would make taking the opioid antagonist drug naloxone (Narcan) risky for the patient?
- Opioid dependence
- Respiratory depression due to nonopioid drugs
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What are some contraindications that would make taking the glucocorticoid drug prednisone (Deltasone) risky for the patient?
- Recent live virus immunization
- Systemic fungal infection
- Cataracts
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What is a contraindication that would make taking the uricosuric drug allopurinol (Zyloprim) risky for the patient?
What is a contraindication that would make taking the uricosuric drug allopurinol (Zyloprim) risky for the patient?
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