-
What drugs or food have the potential to interact with the polyene antibiotic drug amphotericin B (Fungizone)?
- Nephrotoxicity increased with the use of nephrotoxic chemotherapy drugs, aminoglycosides, cyclosporine, furosemide, and vancomycin.
- Corticosteroids increase the risk for hypokalemia.
- Digitalis toxicity is increased with the presence of hypokalemia.
-
What drugs or food have the potential to interact with the antimycobacterial drug isoniazid (INH)?
- Alcohol increases the risk for toxicity and adverse reactions.
- Disulfiram (Antabuse) may cause psychosis or ataxia.
- Isoniazid (INH) with phenytoin (Dilantin) may cause phenytoin toxicity.
- Antacids containing aluminum (Amphojel, Maalox, Mylanta) decrease absorption.
- Two other tuberculosis drugs, ethionamide (Trecator) and cycloserine (Seromycin), may increase CNS adverse symptoms.
-
What drugs or food has the potential to interact with the cephalosporin drug cephalexin (Keflex)?
Probenecid causes prolonged effect of most cephalosporins.
-
What drugs or food have the potential to interact with the antiparasitic drug metronidazole (Flagyl)?
- Alcohol causes a disulfiram (Antabuse)-type reaction.
- Citalopram (Celexa), ritonavir (Norvir), IV nitroglycerin, sulfamethoxazole, or trimethoprim may also cause disulfiram-type reactions.
- Phenobarbital decreases blood levels.
- Metronidazole increases lithium levels.
- Fluorouracil and azathioprine may cause temporary neutropenia and increase risk for infection.
- Disulfiram may cause a psychotic reaction.
- Multiple solution incompatibilities with IV form.
-
What drugs or food have the potential to interact with the antibacterial drug tetracycline (Sumycin)?
- Antidiarrheals containing kaolin decrease absorption.
- Supplements and antacids containing calcium, magnesium, or aluminum decrease absorption.
- Dairy products and supplements with iron or zinc decrease absorption.
- Tetracycline decreases effectiveness of oral contraceptives
-
What drugs or food have the potential to interact with the antiparasitic drug chloroquine (Aralen)?
- Antacids and laxatives that contain magnesium or aluminum decrease absorption.
- Lemon juice decreases effectiveness.
-
What drugs or food have the potential to interact with the azole drug ketoconazole (Nizoral)?
- Antacids, proton pump inhibitors, and H2 antagonists greatly decrease absorption; take ketoconazole at least 2 hr before taking any of these drugs.
- Rifampin (Rifadin) decreases blood levels.
- Echinacea increases the risk for liver toxicity.
-
What drugs or food have the potential to interact with the antibacterial drug vancomycin (Vancocin)?
- Metformin may cause and increase the risk for lactic acidosis.
- Drugs that are toxic to hearing or kidney increase the risk for ototoxicity or nephrotoxicity.
- Vancomycin is incompatible in a solution with multiple other IV drugs.
-
What drugs or food have the potential to interact with the monobactam drug aztreonam (Azactam)?
- Incompatible in IV solution with multiple other drugs.
- Probenecid may increase blood levels of aztreonam.
- Some other antibiotics (imipenem, cefoxitin) may decrease the effectiveness of aztreonam.
-
What drugs or food have the potential to interact with the penicillin drugs amoxicillin (Amoxil) and amoxicillin and clavulanic acid (Augmentin)?
- Probenecid increases penicillin blood levels.
- Tetracyclines may decrease therapeutic effects.
-
What drugs or food have the potential to interact with the urinary tract antiseptic nitrofurantoin (Macrodantin)?
- Antacids decrease absorption.
- Probenecid increases the chance of toxicity.
-
What drugs or food have the potential to interact with the aminoglycoside drug Gentamicin (Garamycin)?
- Vancomycin (Vanocin), ethacrynic acid (Edecrin), furosemide (Lasix), and other ototoxic drugs increase the risk for ototoxicity.
- Amphotericin B (Fungizone), NSAIDS or other nephrotoxic drugs increase the risk for nephrotoxicity.
- Cephalosporins, vancomycin, and penicillin enhance the bactericidal effect of gentamicin.
- Penicillin, cephalosporins, heparin shouldn't be mixed in the same IV solution with gentamicin.
- Prolonged respiratory paralysis can occur when used in combination with neuromuscular blockers (pancuronium, succinylcholine [Anectine]).
-
What drugs or food have the potential to interact with the antimycobacterial drug rifampin (Rifadin)?
- Decreases blood levels of oral contraceptives, warfarin (Coumadin), and several HIV drugs (protease inhibitors).
- Isoniazid and pyrazinamide increase risk for liver toxicity.
-
What drugs or food have the potential to interact with the fluoroquinolone drug ciprofloxacin (Cipro)?
- Antacids, iron preparations, calcium (including dairy products), and sucralfate (Carafate) decrease oral absorption.
- Increases theophylline levels and the risk for CNS symptoms.
- Increases warfarin (Coumadin) levels.
-
What drugs or food have the potential to interact with the sulfonamide drug trimethoprim and sulfamethoxazole (Bactrim, Septra)?
- Alcohol with the drug may cause a disulfiram (Antabuse)-type reaction.
- May increase effects of warfarin, phenytoin, tolbutamide (and other sulfonylurea oral antidiabetic drugs).
- Taken with methotrexate, may cause increased immunosuppression.
- Reduces effectiveness of oral contraceptives.
-
What drugs or food has the potential to interact with the carbapenem drug imipenem (Primaxin)?
Monobactam, penicillin, and cephalosporin antibiotics may decrease the effects of imipenem.
-
What drugs or food have the potential to interact with the macrolide drug erythromycin (E-Mycin)?
- Decreases blood levels of chloramphenicol and clindamycin antibiotics.
- Increases blood levels of multiple drugs, including digoxin, warfarin, and theophylline.
- Drinking grapefruit juice may increase adverse effects.
- Drugs that inhibit the enzyme CYP3A4 increase erythromycin levels (verapamil, azole antifungals, protease inhibitors for HIV, diltiazem)
-
What drugs or food have the potential to interact with the antiviral drug acyclovir (Zovirax)?
- Probenecid increases blood levels.
- Zidovudine increases CNS effects.
- Drugs that are nephrotoxic increase risk for renal toxicity
|
|
