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What is found on the outer layer of a serum lipoprotein?
- Phospholipids
- Free cholesterol
- Apolipoproteins
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What is found in the core of a serum lipoprotein
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Rate the serum lipids in the order of size
- Chylomicrons
- VLDL
- IDL
- LDL
- HDL
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What are chylomicrons built from and where does this building occur? What are they called once they are broken down?
- Made from: Dietary lipids
- Made in: Small intestine epithelia
- Degregation: Chylomicron remnants
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What is stored in VLDL, and what occurs as their TAGs are removed?
- Storage: Denovo synthesized TAG
- LDL remmoves TAGs to make IDL
- IDL lose more TAGs to make LDL
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What is the main compound in LDL?
Cholesterol and cholesterol ester
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Name 4 functions of HDL:
- 1. Transfer apo-LP
- 2. Pick up lipids and cholesterol
- 3. Convert cholesterol to cholesterol esters
- 4. Transfer cholesterol esters to other LP
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What apo-LP does the LDL-R have a high affinity for? What molecules will it bind? What is its location?
- ApoLP: Loves B100, doesn't like E
- High Affinity: LDL, but will also take VLDL, IDL and chylomicron reminants
- Location: Liver and adrenals
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What apo-LP does the LDL-R related protein have a high affinity for? What molecules will it bind? What is its location?
- ApoLP: Loves apoE
- High Affinity: Chylomicron reminants, but will also take VLDL
- Location: Liver, brain, lung
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What is the role of the macrophage scavenger R in terms of LDL?
It bind LDL with oxidative damage and form foam cells and atherosclerosis
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Where is the location of lipoprotein lipase, what apoLP does it prefer, what molecules does it have a high affinity for and what is its function?
- Location: Vacular epithelium of muscle and adipose tissue
- Apo-LP: Apo-C2
- High Affinity: Chylomicrons and VLDL
- Function: Remove free fatty acids from chylomicrons and VLDL
- In Adipose: It will remake TAG
- In Muscle: It will oxidize it for energy
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What is the location and function of heptic trigrlyceride lipase (HTGL)?
- Locaton: Liver
- Function: Degreade TAG from paritally degraded lipoproteins
- Lazy! :)
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What does cholesterol ester transferase do?
Exchange cholesterol esters for TAGs between HDL and VLDL/IDL/LDL
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What does Lecithin cholesterol acyl transferase do?
- Esterifies the free cholesterols from HDLs surface
- Changes it's shape from disk to ball!
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What does lysosomal acid lipase do?
Changes LDL's cholesterol ester to cholesterol + fatty acid
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What is the general role of the acyl-coa cholesterol acyl transferase (ACAT)?
To form cholesterol oleate to store small amounts of cholesterol
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