Micro T2, L34 Acquired pneumonia.txt

  1. Name the three ways that pneumonia bacteria enter the body?
    • Aerosol
    • Aspire
    • Dissimenate
  2. What are the four common atypical CAP bacteria?
    • Legionella pneumophila
    • Mycoplasma pneumoniae
    • Chlamydia trachomatis
    • Chlamydophila pneumoniae
  3. Of the four CAP bacteria, which is most commonly found?
    Leigonella pneumophila
  4. What helps opsonize L. Pneumophila?
  5. How does L. Pneumophila infect host?
    • Inhibits phagolysosome
    • Lyses phagosome & releases toxins
  6. Two diseases caused by L. Pneumophila?
    • 1) Pontiac fever: self-limited illness
    • 2) Legionnaires' Disease: sever, atypical pneumonia = 75% mortality from shock or resp. failure
  7. What cell does Legionnaires' Disease infiltrate?
  8. T/F immunity to L. pneumophila is long lasting?
    T, through CMI system
  9. Gold standard for L. pnemophila testing?
  10. What Titer demonstrates infection w/ L. pneumophila?
    IFA of 128, still must be 4-fold increase
  11. DOC for L. pneumophila?
  12. T/F M. Pneumoniae are resistant to cell-wall inhibitors
    T, b/c they do not have cell walls
  13. What is the special culture appearance of M. pneumoniae
    fried egg
  14. What CAP bacteria most commonly causes atypical CAP?
    M. pneumoniae
  15. What is specifically found in the plasma membrane of M. pneumoniae?
  16. T/F infection w/ M. pneumoniae causes long lasting immunity?
  17. How does M. pneumoniae infiltrate the lungs?
    Binds to ciliated epithelium by P1 adhesins, releases H2O2 + O2 = ciliostasis and damage
  18. Two tests used to ID M. pneumoniae and how they work?
    • Elisa: >32 or 4-fold increase
    • Cold agglutination assay: detect IgM binding to I antigen on RBCs
  19. DOC for M. pneumoniae?
  20. Where are chlamydial bacteria found?
    Intracytoplasmic inclusions
  21. T/F Chlamydial bacteria have peptidoglycan layer and LPS since they are G -?
    F, they do not have peptidoglycan layer but do have LPS
  22. What is the pathogenesis of Chlamydial disease?
    Direct cell destruction & inflammation
  23. T/F Chlamydial bacterial infection immunity is not long lasting?
  24. Primary defense against chlamydial infection?
    PMN activity
  25. How is chlamydia trachomatis transferred?
    Transfer: mother to infant at birth
  26. Main disease caused by C. Trachomatis?
    Infantile pneumoniae
  27. main child symptoms w/ C. trachomatis?
    • staccato cough
    • afebrile
    • Eosinophilia
  28. Main disease caused by C. pneumoniae?
    Bronchitis, atypical pneumonia, sinusitis
  29. How is respiratory disease of Chlamydia detected?
    • 1) Microimmunofluorescent assay for IgM/IgG
    • IgM >16
    • IgG > 512
    • 4-fold increase
    • 2) Microscope: intracellular inclusions
  30. DOC for Chlamydia treatment?
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Micro T2, L34 Acquired pneumonia.txt
Micro T2, L34 Acquired pneumonia