Prodrugs

  1. Heroin
    • Prodrug for morphine
    • Has acetyl groups instead of alcohols
    • Crosses BBB more readily, then hydrolyzed into morphine
  2. Nabumetone
    Prodrug designed to reduce toxicity
  3. Chloramphenicol
    Prodrug designed to be more water soluble
  4. Bambuterol
    • Prodrug for Terbutaline
    • Terbutaline experiences high first-pass metabolism
    • Prodrug administration results in prolonged plasma concentrations of the drug
Author
jaguavai
ID
106184
Card Set
Prodrugs
Description
Prodrugs from Pharm 410
Updated