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Monoamines
Catecholamines (tyrosine) & Indolamines (tryptophan)
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Catecholamines
Dopamine, Epinephrine (adrenaline), & Norepinephrine
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Amino Acids
Glutamate, GABA, & Glysine
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Soluble Gases
Nitric Oxide
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Acetylcholine
The primary neurotransmitter secreted by the efferent axons of the CNS
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Ach Receptors
Nicotinic (nAchR) and Muscarinic (mAchR)
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nAchR
Ach receptor that is stimulated by nicotine and blocked by curare
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mAchR
Ach receptor that is stimulated by mascarine and blocked by atropine
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Three systems for Dopamine
Nigrostratial, Mesolimbic, & Mesocortical
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Nigrostriatal System
Plays a role in control of movement
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Mesolimbic System
Plays a role in reinforcing effects of drugs that are commonly abused
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Mesocortical System
Short term memory and problem solving
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Norepinephrine (noradrenaline)
Found in the ANS and brain. Main Nucleus is Locus Coeruleus in dorsal pons, for arousal & attention
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Epinephrine
A hormone secreted by the adrenal medulla; Not used as much in the CNS as norepinephrine
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Serotonin
5-HT or 5-hyrdoxytryptamine; Thought to play a role in regulation of mood, control of eating, sleeping, dreaming, and arousal
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Drugs for Serotonin
PCPA, Fluoxetine, LSD, & MDMA
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PCPA
A drug that inhibits the activity of tryptophan hydroxylase, interfering with the synthesis of 5-HT and serves as a serotonergic antagonist
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Fluoxetine (Prozac)
A drug that inhibits reuptake of 5-HT. Used to treat depression, OCD, and some anxiety disorders
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LSD
A drug that stimulates 5-HT2A receptors
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MDMA (ecstasy)
A drug that serves as a noradrenergic and serotonergic agonist; has excitatory and hallucinogenic effects
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