autoimmune diseases

  1. Multiple sclerosis
    • affects: CNS (oligo)
    • pathology: demyelination
  2. Acute Idiopathic Polyneuritis (Guillian-Barre' syndrome)
    • affects: PNS
    • pathology: demyelination
  3. Myasthenia gravis
    • Affects: Neuromuscular junction, AchR
    • pathology: destruction of AchR, impaired transmission
  4. Hashimoto's thyroiditis
    • affects: hypothyroidism
    • pathology: anti-thyroglobulin; anti-thyroid epithelium
  5. Grave's disease
    • affects: BM of renal glomeruli (some pulmonary alveoli)
    • pathology: kidney/respiratory failure
  6. Addison's disease
    • affects: adrenal glands
    • pathology: anti-adrenal cell mem and lymphocyte/monocyte cortical infiltration
  7. DM-1
    • affects: pancreati islet (beta cells)
    • pathology: beta cell destruction via Ab, TH1, and CD8+ T cells
  8. Sjogren's syndrom
    • affects: salivary glands
    • pathology: glandular inflammation
  9. Autoimmune hemolytic anemia
    • affects: erythrocytes
    • pathology: erythrocyte destruction and anemia
  10. Thrombocytopenias
    • affects: platelets or megakaryocytes
    • pathology: platelet destruction/ abnormal bleeding
  11. Chronic atrophic gastritis; pernicious anemia
    • affects: gastric mucosa
    • pathology: loss of gastric secretory func, failure of vitamin B12 absorption bc loss of intrinsic factor or intrinsic factor producing cells
  12. intestinal granulomatous disease (Chron's)
    • affects: mucosal mem of terminal ileum
    • pathology: mucosal ulceration, obstructive granuloma
  13. Rheumatic fever
    • affects: heart
    • pathology: myocarditis, scarring of heart valves
  14. Pemphigus vulgaris
    • affects: epidermis
    • pathology: blistering of skin
  15. Systemic lupus erythematosis
    • affects: variety of organs
    • pathology: autoreactivity; acute immune complex disease
  16. Rheumatoid arthritis
    • affects: joints then spreads to cartilage and neighboring bone and muscle
    • pathology: immune complex disease in synovium, Ab against IgG, inflammatory T cells seen
Card Set
autoimmune diseases
MS1/Mod 2: Immunology; autoimmune diseases