-
Multiple sclerosis
- affects: CNS (oligo)
- pathology: demyelination
-
Acute Idiopathic Polyneuritis (Guillian-Barre' syndrome)
- affects: PNS
- pathology: demyelination
-
Myasthenia gravis
- Affects: Neuromuscular junction, AchR
- pathology: destruction of AchR, impaired transmission
-
Hashimoto's thyroiditis
- affects: hypothyroidism
- pathology: anti-thyroglobulin; anti-thyroid epithelium
-
Grave's disease
- affects: BM of renal glomeruli (some pulmonary alveoli)
- pathology: kidney/respiratory failure
-
Addison's disease
- affects: adrenal glands
- pathology: anti-adrenal cell mem and lymphocyte/monocyte cortical infiltration
-
DM-1
- affects: pancreati islet (beta cells)
- pathology: beta cell destruction via Ab, TH1, and CD8+ T cells
-
Sjogren's syndrom
- affects: salivary glands
- pathology: glandular inflammation
-
Autoimmune hemolytic anemia
- affects: erythrocytes
- pathology: erythrocyte destruction and anemia
-
Thrombocytopenias
- affects: platelets or megakaryocytes
- pathology: platelet destruction/ abnormal bleeding
-
Chronic atrophic gastritis; pernicious anemia
- affects: gastric mucosa
- pathology: loss of gastric secretory func, failure of vitamin B12 absorption bc loss of intrinsic factor or intrinsic factor producing cells
-
intestinal granulomatous disease (Chron's)
- affects: mucosal mem of terminal ileum
- pathology: mucosal ulceration, obstructive granuloma
-
Rheumatic fever
- affects: heart
- pathology: myocarditis, scarring of heart valves
-
Pemphigus vulgaris
- affects: epidermis
- pathology: blistering of skin
-
Systemic lupus erythematosis
- affects: variety of organs
- pathology: autoreactivity; acute immune complex disease
-
Rheumatoid arthritis
- affects: joints then spreads to cartilage and neighboring bone and muscle
- pathology: immune complex disease in synovium, Ab against IgG, inflammatory T cells seen
|
|