-
SCF
- factor on bone marrow stromal cell that plugs into
- early pro-B cell
-
IL-7
stimulates B-cell development
-
TdT
- terminal deoxynucleotidal transferase
- DNA recombination
-
RAG 1/2
recombination activating genes specific to lymphocytes
-
TAP
move endogenously digested peptide from cytosol to ER
-
Ii
invariant chain; blocks peptide binding groove on MHCII until fusion with low-pH lysosomes
-
ITAM
immunotyrosine activation motif; tyrosine phosphorylation in TCR antigen recognition
-
CD34 is found...and it's job is...
- anchored in the endothelial cell
- facilitates rolling
-
GlyCAM-1 is found... and it's job is...
- anchored in endothelial cell
- facilitates rolling
-
LFA-1 is found... is activated by... binds to...
- on lymphocyte
- chemokines
- ICAM-1
-
L-selectin is found...binds to... is low in...
- on lymphocyte
- CD34
- effector T cells (not naive)
-
NFAT is a...generates...
- transcription factor
- IL-2 (T cells) and IgM (B cells)
-
NF-kappaB is a... and generates
- transcription factor
- IL-2 (T cells) and IgM (B cells)
-
AP-1 is a... and generates...
- transcription factor
- IL-2 (T cells) and IgM (B cells)
-
VLA-4 is found... binds to... is high/absent in...
- on lymphocyte
- VCAM-1
- high in effectors, absent in naive T cells
-
VCAM-1 is found... and binds to
- anchored in endothelial cell
- binds to VLA-4
-
IFNgamma activates, promotes, inhibits...
- activates resting macrophage
- promotes TH1 differentiation
- inhibits TH2 proliferation
-
IFNgamma is produced by
TH1 cells
-
CD40L
- produced by TH2
- stimulates B cell proliferation and differentiation (somatic hypermutation)
- found in responses to parasites
-
TGFbeta
inhibits activation/growth of TH1
-
Zap70
signal transduction in T cells
-
Syk
signal transduction in B cells
-
CD5
characteristic of B1 cells
-
EF-Tu, eEF-1delta
brings in aa-tRNA-GTP
-
EF-TS, eEF-1betagamma
exchange factor that recycles tRNA-GDP
-
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