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ANS pharmacology

  1. Nicotinic receptors (2) what type and what they are associated with
    • Ionotropic
    • 1) Nicotinic Neural- ganglionic neurons & adrenal medulla

    2) Nicotinic Muscular- skeletal neuromuscular endplate
  2. Muscarinic receptors (3) what type and what are they associated with.
    • Metabotopic
    • 1) M1 (Ca2+ in) presynaptic ganglion

    2) M2 (K+ and cAMP- inhibitory)- myocardium & presynaptic terminals

    3) M3 (Ca2+ Excitatory) - smooth muscle, exocrine glands, & vascular endothelium
  3. Neostigmine
    • Reversible AchE inhibitor
    • (4th generation)
  4. Pilocarpine
    • nonselective muscarinic receptor agonist
    • 3rd generation
  5. Succinlycholine
    Noncompetitive cholinergic antagonist
  6. d-Tubocurare
    competitive antagonist of Nm
  7. What are the main autonomic receptors in the gallbladder?
    M3
  8. What are the main autonomic receptors in the sinoatrial node
    M2
  9. What are the main autonomic receptors in vascular smooth muscle?
    Alpha-1 and beta-2
  10. What are the main autonomic receptors in the lower esophageal sphincter
    M3
  11. What are the main autonomic receptors intestinal peristalsis
    M3
  12. What are the main autonomic receptors in the increase in gluconeogenesis
    Beta-2
  13. What autoreceptor inhibits the release of NEP
    Alpha-2
  14. What autoreceptor inhibits the release of Acetylcholine
    M2
  15. What autoreceptor stimulates the release of NEP
    Beta- 2
  16. What autoreceptor stimulates the release of Ach
    Nn
  17. What are the main autonomic receptors in bronchial muscle
    M3 and beta-2
  18. What are the main autonomic receptors in the sphincter of the iris
    M3
  19. What are the main autonomic receptors in the AV node
    M2 and beta-1
  20. What are the main autonomic receptors in purkinje fibers
    Beta-1
  21. What vessels are predominated by alpha 1
    Vessels in the skin, GI and GU
  22. What vessels are predominated by Beta-2 receptors
    Vessels of skeletal and liver
  23. What are the main autonomic receptors in gastric parietal cells
    M3
  24. What are the main autonomic receptors in the radial muscle of iris
    alpha-1
  25. What are the main autonomic receptors in the beta cells of the pancreas
    alpha-2
  26. What receptors are located on platelets
    alpha-2 receptors
  27. what are the somatic receptors in skeletal muscle?
    Nm
  28. What are the autonomic receptors in skeletal muscle
    alpha-1 and beta-2
  29. What are the main autonomic receptors in the salivary glands
    M3
  30. What are the main autonomic receptors in ciliary muscle
    M3
  31. What are the main autonomic receptors in detrusor muscle
    M3
  32. Palpitation occurs when you block which receptor
    M2 receptor
  33. Dry mouth, blurred vision, and constipation occurs when you block which receptor?
    M3 receptors
  34. Drugs that inhibit cholinesterase cause what to happen in the bladder
    Ach inc --> Nn and M3 activated --> contraction of detrusor muscle
  35. How does activation of B2 receptor lead to palpitations?
    • 1) The vasodilation of skeletal vessels leads to reflex tachy cardia
    • 2) B2 plays a small role in direct increase in heart rate.
  36. What can relax the detrusor muscle
    M3 antimuscarinics
  37. What effect do antimuscarinics have on the heart.
    Decrease in AV conduction
  38. Antimuscarinics are contraindicated in
    People with ulcerative colitis (IBD)
  39. atropine is useless at what receptors
    Alpha, beta, and Nn receptors
Author
lazzsant
ID
104177
Card Set
ANS pharmacology
Description
ANS pharmacology
Updated

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