-
IL-1
- Source: monocytes, macrophages
- Activates immune cells
- Endogenous pyrogen
- Acute phase proteins
-
IL-2
- Source: TH cells
- Induces proliferation
- Enhances function
-
IL-3
- Source: TH cells, NK cells
- Supports growth and differentiation of myeloid cells
-
IL-4
- Source: TH2 cells, mast cells
- Activation, differentiation of B cells
- TH2 response
- Class switch to IgG1, IgE
-
IL-5
- Source: TH2 cells
- Proliferation, differentiation of B cells
- Class switch to IgA
- Eosinophil activation
-
IL-6
- Source: monocytes, macrophages, TH2 cells
- Pyrogen
- Differentiation of plasma cells
- Acute phase response
-
IL-7
- Source: Thymus, bone marrow
- Proliferation of B, T cell progenitors
-
IL-8
- Source: macrophages, endothelium
- Chemokine (neutrophils)
-
IL-10
- Source: TH2 cells
- Suppresses TH1 cytokine production
-
IL-11
- Source: bone marrow
- Increases thrombocyte production
-
IL-12
- Source: macrophages
- Stimulates cell mediated immunity
-
IL-17
- Source: TH17 cells
- Increases inflammation and tissue damage
- Associated with some autoimmunity
-
IFN-a, b
- Source: Leukocytes, fibroblasts
- Inhibits virion synthesis
- Acts on uninfected cells
-
IFN-g
- Source: TH1, CTL, NK cells
- CMI
- Inhibits TH2
- Increases MHC I, II expression
-
TNF-a, b
- Source: CMI cells
- Enhances CMI
- Tissue inflammation and cell death
- Acute phase proteins
-
G-CSF, GM-CSF
- Source: macrophages, TH cells
- Proliferation of granulocyte progenitors in marrow
- Counteracts neutropenia
-
IL-25
Induces TH2 cytokine release
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