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What is Benztropine (Cogentin)?
- -Anticholinegic, used to treat EPSE
- -Most frequently prescribed.
- -Do not give with TD
- -Can be given Oral, IM or IV
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What is Biperiden (Akineton)?
- -Anticholinergic drugs
- -Used to treat EPSE
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What is Diphenhydramine (Benadryl)?
- -Anticholinergic
- -Used to treat EPSE
- -Can cause some sedation
- -Less potent than Benztropine (Cogentin)
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What is Trihexyphenidyl (Artane)?
- -Anticholinergic
- -Not available in parenteral form, use for acute dystonias is limited.
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What is chlorpromazine (Thorazine)?
- -Traditional, low potency
- -Results in more anticholinergic and antiadrenergic effects, and less EPSEs
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What is Thioridazine?
- -Traditional, low potency
- -Not prescribed as much, can cause death
- -Has been therapeutic in behavioral problems.
- -Upper limit of 800 mg/day because of pigmentary retinopathy (decreased visual acuity, impaired night vision, pigment deposits on the fundus.)
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What are the moderate potency traditional antipsychotics?
- -Loxapine (Loxitane)
- -Molindone (Moban)
- -Perphenazine (Trilafon)
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What is Fluphenazine (Prolixin)?
- -Traditional, high potency
- -Long acting Fluphenazine decanoate (prolixin decanoate) injection can be given every 2-3 weeks
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What is Haloperidol (Haldol)?
- -Traditional, high potency
- -Cause more EPSE and fewer anticholinergic side effects.
- -Used extensively in older adults and pediatric psychiatry.
- -Threat of aggressive behavior, can be used in combination with Ativan.
- -Haloperidol Decanoate, long acting form
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What is Chlorpromazine?
- -First atypical antipsychotic
- -Reduced or no risk for EPSE
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What is Clozapine (Clozaril)?
- -Atypical, works on both positive and negative symptoms
- -Causes agranulocytosis
- -Excessive salivation
- -Myocarditis
- -less risk for EPSE
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What is Risperidone (risperdal)?
- -Atypical antipsychotic
- -Favorable profile for positive and negative symptoms
- -Low side effects
- -A long acting IM (Risperdal Const) available
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What is Olanzapine (Zyprexa)?
- -Atypical, similar to Risperdal
- -Causes weight gain, Metabolic syndrome
- -IM and oral form
- -approved to treat acute mania
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What is Quetiapine (Seroquel)
- -Atypical
- -Few anticholinergic effects
- -Orthostatic hypotension
- -Appears to improve serum prolactin levels and cognitive factors
- -Produces a sedative effect
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What is Ziprasidone (geodon)?
- -Atypical
- -Causes few EPSEs, few anticholinergic side effects
- -Less weight gain than other atypical
- -Lengthens the OTc interval
- -Absorption is increased when give with food
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What is Aripiprazole (Abilify)?
- -Dopamine system stabilizer (DSS), third generation of antipsychotics
- -Increases dopamine where needed and decreases dopamine where needed
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What is Asenapine (Saphris)?
- -Latest atypical drug
- -Sublingual tablet
- -Approved for acute schizophrenia and bipolar disorder
- -Low EPSEs, higher cases of akathisia.
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