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IL-1
- Produced by activated macrophages, neutrophils and epithelium
- Pyrogenic
- Targets other immune cells for proliferation, production
- TNF-a release
- IL-2 production
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IL-2
- TCR induction increases IL-2 and IL-2R production --> autocrine
- Activate T cells
- Induces IFN-g, IL-2, IL-6, IL-4, IL-5
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IL-3
- Source: Th cells, NK cells
- Growth and differentiation of myeloid cells
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IL-4
- Source: TH2 cells
- B cell activation, differentiation, class switching to IgG1 and IgE
- Inhibits development of TH1
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IL-5
- Source: TH2 cells
- proliferation, differentiation, class switch to IgA
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IL-6
- Source: monocytes, macrophages, TH2 cells
- Endogenous pyrogen
- Promotes plasma cell formation
- Induces acute phase response
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IL-7
- Source: primary lymph organs
- Stimulates B and T lymphocyte progenitors in marrow
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IL-8
- Source: macrophage, endothelial cells
- Chemokine (neutrophils)
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IL-10
- Source: TH2 cells
- Suppresses cytokine production of TH1
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IL-12
- Source: macrophages
- Stimulates CMI
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IL-17
- Source: TH17 cell
- Inflammation and tissue damage
- Associated with some autoimmune diseases
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IFN-a, b
- Source: leukocytes, fibroblasts
- Inhibits viral protein synthesis
- Acts on uninfected cells
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IFN-g
- Source: TH1 cells, CTL, NK cells
- Stimulates CMI, inhibits TH2, increases MHC I, II expression
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TNF-a, b
- Source: TH1 cells, activated macrophage, CTL
- Enhances CMI
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G-CSF and GM-CSF
- Source: Macrophage and TH cells
- Induces myelocyte proliferation
- Counters neutropenia following ablation
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