-
Diphtheria toxin
- Corynebacteria diphtheriae
- ADP riposyl transferase
- inactivates EF-2
- Targets: heart, nerves, epithelium
-
Exotoxin A
- Pseudomonas aeruginosa
- ADP ribosyl transferase
- inactivates EF-2
- Target: liver
-
Shiga toxin
- Shigella dysenteriae
- binds 60s subunit
- enterotoxic, cytotoxic, neurotoxic
- bloody diarrhea
-
Verotoxin (shiga like)
- Enterohemorrhagic E. coli
- binds 60s subunit
-
Tetanus toxin
- Clostridium tetani
- blocks release of glycine and GABA
- spastic paralysis
-
Botulism toxin
- Clostridium botulinum
- blocks release of ach
- flaccid paralysis
-
TSST-1
- Staph aureus
- induces IL-1, IL-6, TNF-a, IFN-g
- decreases liver clearance of LPS
- fever, rash, shock, cardiotoxicity
-
Exotoxin A (strep)
AKA erythrogenic toxin
AKA pyrogenic toxin
- Strep pyogenes
- induces inflammatory factor release
- fever, rash, LPS sensitivity, cardiotoxicity
-
Heat labile toxin (LT)
- Enterotoxigenic E. coli
- ADP ribosylates GTP binding protein
- stimulates adenylate cyclase
- secretory diarrhea
-
Cholera toxin
- Vibrio cholera
- ADP ribosylates GTP binding protein
- stimulates adenylate cyclase
- secretory diarrhea
-
Anthrax toxin
- Bacillus anthracis
- EF = edema factor = adenylate cyclase
- LF = lethal factor
- PA = protective antigen (B component)
- decreases phagocytosis
- edema, cytotoxicity
-
Pertussis toxin
- Bordetella pertussis
- ADP ribosylates Gi
- adenylate cyclase free from inhibition
- histamine sensitization
- lymphocytosis (inhibits chemokine receptors)
- islet activation
-
Alpha toxin
- Clostridium perfringens
- lecithinase
- damages cell membranes
- myonecrosis
-
Alpha toxin (pore)
- Staph aureus
- forms pores in membrane
- cell lysis
-
EF-2 inhibitors
- Diphtheria toxin
- Exotoxin A
-
-
Neurotoxins
- tetanis toxin
- botulinum toxin
-
Superantigens
- TSST-1
- Exotoxin A (pyrogenic)
-
cAMP inducers
- LT
- Cholera toxin
- Anthrax toxin
- Pertussis toxin
-
Cytolysins
- Alpha toxin
- Alpha toxin (pore)
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