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Need for dosage form
- Protection of drug
- Taste/Odor
- Appropriate dose
- Age of patient
- Rate Controlled Drugs
- Safety
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Preformulation Studies
- Physical Description
- Microscopic
- Melting Point
- Phase Rule
- Particle Size
- Polymorphism
- Solubility
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How to effect the solubiblity of drug
- pH
- Particle Size
- Salt ester forms
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How to effect the drug stability
- Hydrolysis
- Oxidation
- Polmerization
- Decarboxilation
- Deamination
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Enhancement of Stability
- Hydrolysis
- Waterproof coating
- Use substitute liquid, glycerin, oil, alcohol
- Preparation of suspension, non-aqueous vehicle
- Dry powder for reconstitution
- Refrig
- Buffers, controlling pH
- Oxidation
- Antioxidants
- Light resistant containers (opaque)
- Buffer controlling pH
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Stability Concerned to Pharmacist
- Chemical
- Physical
- Microbological
- Toxicologic
- Therapeutic
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No color Additives
- Parential
- Opthalmic
- New borns
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Drug (the next steps for it to get absorbed)
- Dissolution into body fluid
- Transported by body fluid
- Cross transvers membranes (phospholipid bilayers)
- Escape unwanted distribution
- Endure metabolic attack (first pass effect)
- Penetrate in adequate concentration into sites of action
- Interact specifically
- Alteration of cellular funcation
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Absorption
- Disintigration
- Deaggration
- Wetting
- Dissolution
- Solution
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