Test I

  1. trade name
    manufacturer name
  2. molecules that contain at least one atom of nitrogen and carry a positive charge all times
    quaternary ammonium compounds
  3. proton donor
  4. proton acceptor
  5. process of an acid giving up a proton or a base accepting a proton and converting the acid or base into a charged particle
  6. two pathologic conditions in which low blood flow can affect drug therapy
    abscesses and tumors
  7. inflammation of the colon caused by antibiotics (suprainfection; bacteria C. difficile)
    pseudomembranous colitis
  8. two types of Oral Contraceptive
    combination- contain both an estrogen and a progestin

    progestin- only contain a progestin
  9. Two types of Hormone replacement therapy:
    • estrogen alone
    • estrogen with progestin
  10. why is progestin given along with estrogen in hormone replacement therapy? and what can it lead to if progestin is not given?
    to counterbalance the estrogen-mediated stimulation of the endometrium

    can lead to hyperplasia and cancer
  11. act on the uterus to cause the proliferation of the endometrium
  12. together these two hormones regulate the menstraul cycle
    Follicle Stimulating Hormone and Luteinizing Hormone
  13. acts on ovarian follicles, causing them to mature and secrete estrogens
  14. influences corpus luteum to secrete progesterone
  15. support the development and maintenance of the female reproductive tract and secondary sex charachteristics, required for the growth and maturation of the uterus, vagina, fallopian tubes, and breasts
  16. prepares the uterus for implanctation of a fertilized ovum and help maintain the uterus throughout pregnancy
  17. injection given to neonates immediately after delivery
    phytonadione (Vit k1)
  18. suppression of preterm labor; uterine relaxants
  19. induction/augmentation of labor, control of postpardum bleeding and induction of abortion; uterine stimulants
  20. receptor antagonist, peptide hormone produced by the posterior pituitary.

    Increases the force, frequency, and duration of uterine contractions. used to help uterus close after delivery and to control postpartum hemorrhage
    Pitocin (oxytocin)
  21. can suppress labor up to 48 hours
  22. treatment of fungal infections. highly toxic and dangerous with side effects including flushing, fever, chills, hypotension, red man's syndrome
    amphoterin B
  23. used for suprainfections with susceptible organisms in patients allergic to penicillin.

    inhibits cell wall synthese and promotes bacterial lysis.

    side effects include ototoxicity, flushing, rash, tachycardia, hypotension
  24. suprainfection of the bowel from bacteria C. diffile

    characterized by profuse watery diarrhea, abdominal pain, fever

    treated with vancomycin
    psuedomembranous colitis
  25. polyene antibiotic used for candidiasis
  26. polypeptide antibiotic used for topical treatment of bacterial infections.

    adverse reactions include: renal dysfunction, blood dyscrasias, respiratory distress
  27. a macrolide with a broad antimicrobial spectrum; preferred treatment for a number of infections. safer antibiotic
  28. binds to the 50S ribosomal subunit and therby blocks addition of new amino acids in the peptide chain
  29. can increase the plasma levels and half lives of several drugs thereby posing a risk for toxicity
  30. side effects include nausea, vomitting, diarrhea, abdominal crams, liver toxicity if taken with other hepatotoxic drugs (ex- acetaminophen)
  31. broad spectrum antibiotics that inhibit bacterial protein synthesis
  32. the ratio of the minimum concentration of drug that produces toxic effects and the minimum concentration that produces the desired effect
    therapeutic index
  33. often used to refer to the span of concentration between minimum toxic concentration and minimum effective concentration. the bigger the easier to administer a drug without unwanted toxicity
    therapeutic window
  34. done to find out what kind of organism is causing an illness or infection
  35. test done to check to see what kind of medicine will work best to treat the illness or infection
  36. define the term "generation" as it relates to cephalosporins:
    Each offspring of every generation is becoming more resistant to Beta-lactamase and increasing ability to reach CSF
  37. What is unique about 3 and 4 generation cephalasporins?
    reach clinically effective concentrations in CSF and are becoming reactive against P. aeruginsoa
  38. suppress bacterial growth by inhibiting protein synthesis
Card Set
Test I
Drugs n stuff