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Cyt p 450 inducers?
- Quinidine
- Barbituates
- St. Johns Wart
- Phenytoin
- Rifampin
- Griseofulvin
- Carbamezapine
- Chronic EtOH use
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Cyt p 450 inhibitors
- HIV protease inhibitors
- Ketoconazole
- Erythromycin
- Grapefruit Juice
- Acute EtOH
- Cimetidine
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What is the Infusion Rate? Ko?
Cl x CSS
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What is the MD?
Vd x Css x dosing interval
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What is the Clearance?
Vd x k
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What is t1/2?
0.7 x Vd/CL
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What receptors signal thru the q arm of the G protein?
H1,a1,V1,M1,M3
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What is the signalling pathway for the q arm of G protein?
- phospholipase c--- +IP3-- + Ca
- DAG---- + Protein Kinase C
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What receptors signal thru the stimulatory arm of G protein?
b1, b2, H2, V2, D1
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What is the signalling pathway for the s arm of the G protein?
+AC--- +cAMP----+ protein Kinase A
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What receptors signal thru the Inhibitory arm of the G protein?
M2, A2, D2
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What is the signalling pathway for the Inhibitory arm of the G protein?
----- - AC------ -cAMP------ - Protein Kinase A
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Ach affects what two muscles in the eye on the parasympathetic arm?
- sphincter --pupil--meiosis
- Ciliary muscle--Lens
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NE affects what muscle in the eye?
radial muscle---mydriasis
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Cycloplegia?
paralysis of accomodation
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Keratitis?
corneal Inflammation
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2 Cholinomimetic Drugs for Glaucoma?
MOA?
- Carbachol
- Pilocarpine
- Contract Ciliary muscle--increase flow thru canal of schlemm
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Ach esterase inhibitor for Glaucoma?
MOA
- Ecothiophate
- Increase Outflow
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2 Beta blockers for Glaucoma?
MOA?
- Betaxolol
- Timolol
- Block NE at ciliary epithelium
- decrease Aqueous humor formation
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2 Sympatomimetic for Glaucoma?
- Apraclonidine--blocks NE at prejunction
- Epinephrine---Increase Outflow
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2 carbonic anhydrase inhibitors for Glaucoma?
MOA?
- Acetozolamide
- Dorzolomide
- Decrease HCO3 production --decreased Acqueus Humor
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PGF2 for Glaucoma?
Latanoprost
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Selective Beta 2 agonists for Asthma?
- Metaproterenol
- Albuterol
- Salmeterol
- Terbutaline
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Uptake inhibitor of Choline at the nerve ending?
hemicholinium
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MOA of botulinum toxin?
inhibits release of Ach from the synaptic membrane
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Botulinum toxin binds to what membrane protein?
synaptobrevin
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What is the motor neuron used for signalling skeletal muscle?
alpha neuron
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Treatment for Strabismus?
botulinum toxin
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Hyperhydrosis?
excessive sweating
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Treatment for Hyperhydrosis?
botulinum toxin
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Muscaranic receptors are found in what 3 locations?
- Heart
- secretion glands
- Smooth muscle
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