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Which vitamin does Warfarin (Coumadin) interfere with?
Vitamin K: which is for dependent clotting factors
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List contraindications for Warfarin (Coumadin)
4
- 1. uncontrolled bleeding
- 2. recent CNS, brain or eye surgery
- 3. Severe hepatic disease
- 4. Uncontrolled HTN
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What is the usual initial dose of Warfarin (Coumadin) and then how is it adjusted?
Dose for children?
- Adult: 2-5mg/day for 2-4 days
- Then, adjust daily dose by INR results
Child: 0.2mg/kg (10mg max) for 2-4 days then adjust dose by INR
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What are the therapeutic ranges for PT, PTT, and INR?
- PT: 9.5-11.5
- PTT: 24-35
- INR: 2.0-3.5
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Which INR value is for someone on Warfarin and someone not on anticoagulants?
a. 0.8-1.2
b. 2.5-3.5
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What is the antidote for anticoagulant overdose of Couamadin?
Vitamin K (phytonadione, AquaMEPHYTON)
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What is the BBW for Enoxaprin (Lovenox)?
Don't expel air prior to injection and don't rub injection site
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What is the indication for Enoxaprin?
Tx of DVT, MI, PE
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What is the antidote of Enoxaprin overdose?
Protamine sulfate 1mg for each mg of enoxaprarin by slow IV injection
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What are therapeutic platelet levels?
142-424K
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If platelet count is below this, Enoxaparin should be d/c
100,000
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Lanoxin and Toloxin are trade names for what?
Digoxin
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What is digoxin used to treat?
HF, afib, paroxysmal atrial tachycardia
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What are contraindications and/or cautions for Dig?
- uncontrolled ventricular arrhythmias
- HYPOkalemia
- HYPERcalcemia
- HYPOmagnesemia
- Use of diuretic
- Renal impairment
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How does HYPERcalcemia, HYPOkalemia, HYPOmagnesemima effect digoxin?
All three have a higher risk of digoxin toxicity
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State whether a hypo or hyper state will increase digoxin levels with these electrolytes:
a. K
b. Ca
c. Mg
- a. Hypokalemia
- b. Hypercalemia
- c. Hypomagnesemia
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In children and infants, what BPM will you withhold dig?
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What class is Furosemide? Lab value to look for and range?
What are its indications?
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Femotidine (Pepcid)
Antiulcer
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Lisinopril (Zestril)
ACE for HTN
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Docusate Sodium (Colace)
Laxative
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Hydrocholorothiazide (Microzide)
Diuretic for HTN
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Furosemide (Lasix)
- Loop diuretic: for HTN and edema d/t HF
- Check lytes
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